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Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
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Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
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相关实验视频

Updated: Jun 3, 2025

A Three-Dimensional Spheroid Model to Investigate the Tumor-Stromal Interaction in Hepatocellular Carcinoma
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肝细胞癌发展中的病因依赖微生物组差异

Nevena Todorovic1,2, Serena Martinelli1, Giulia Nannini1

  • 1Department of Experimental and Clinical Medicine, University of Florence, 50134 Florence, Italy.

International journal of molecular sciences
|January 8, 2025
PubMed
概括

肠道微生物群影响慢性肝病,包括病毒性肝炎和非酒精性脂肪性肝病. 微生物失衡有助于肝损伤,肝硬化和肝细胞癌 (HCC) 的发展.

关键词:
肝硬化是肝硬化的一种疾病.有纤维化的纤维化.我们的肠道微生物群.肝细胞癌是肝细胞癌.在cobiome上蒸汽症是一种蒸汽症.

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科学领域:

  • 微生物学和肝病学 微生物学和肝病学
  • 肠 - 肝轴研究研究
  • 瘤病毒在癌症发展中的作用

背景情况:

  • 慢性肝病涉及炎症,损伤和再生,进展到肝硬化和肝细胞癌 (HCC).
  • 肠道微生物群在健康中起着至关重要的作用,其失生症与各种病理有关,包括慢性肝病.
  • 瘤内微生物群,或"瘤生物群",越来越多地被认为对HCC发育和进展的影响.

研究的目的:

  • 审查肠道微生物群对病毒性肝炎 (乙型肝炎和C型肝炎) 进展的影响.
  • 探索非酒精性脂肪性肝病 (NAFLD) 中的微生物失生症及其无声进展.
  • 检查酒精对肝脏的影响及其与微生物群的相互作用,将炎症与肝硬化和癌症联系起来.

主要方法:

  • 关于微生物群和肝脏疾病现有研究的文献综述.
  • 对专注于病毒性肝炎,NAFLD和与酒精有关的肝病的研究进行分析.
  • 在肝细胞癌 (HCC) 发病过程中探索子生物组的作用.

主要成果:

  • 肠道微生物群显著影响病毒性肝炎肝病的进展.
  • 微生物失生症是NAFLD无声和危险进展的关键因素.
  • 酒精诱导的肝损伤涉及与肠道微生物群的复杂相互作用,导致肝硬化和HCC.

结论:

  • 肠道微生物群是各种慢性肝病的病原发生的关键决定因素.
  • 了解瘤生物组为肝细胞癌的发展提供了新的见解.
  • 准微生物失生症为肝病和HCC预防提供了潜在的治疗策略.