Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Hypertension and Regulation of Blood Pressure01:18

Hypertension and Regulation of Blood Pressure

1.9K
Hypertension, the most common cardiovascular disease, is diagnosed through repeated measurements of elevated blood pressure. Its risks, including damage to the kidney, heart, and brain, are directly proportional to blood pressure levels. Starting from 115/75 mm Hg, the risk of cardiovascular disease doubles with each increment of 20/10 mm Hg. The diagnosis relies on blood pressure measurements, not on patient symptoms, as hypertension is often asymptomatic until end-organ damage is imminent or...
1.9K
Hormonal Regulation01:33

Hormonal Regulation

32.9K
The renin-aldosterone system is an endocrine system which guides the renal absorption of water and electrolytes, thus managing blood pressure and osmoregulation. Activation of the system begins in the kidneys with a small cluster of cells adjacent to the afferent and efferent blood vessels of the renal corpuscle. As the nephrons are filtering blood, juxtaglomerular cells monitor blood pressure. If they detect a decrease in pressure, they release the hormone renin into the bloodstream.
32.9K
Introduction to Urinary System01:13

Introduction to Urinary System

2.1K
The urinary system consists of two kidneys, two ureters, the urinary bladder, and the urethra.
The kidneys are bean-shaped organs located in the retroperitoneal space, on either side of the vertebral column, between the T12 and L3 vertebrae. They are partially protected by the rib cage and surrounded by perirenal fat, which provides cushioning. They are responsible for urine formation and play critical roles in regulating blood pressure, electrolyte levels, and hormone production. The ureters...
2.1K
Antihypertensive Drugs: Potassium-Sparing Diuretics01:28

Antihypertensive Drugs: Potassium-Sparing Diuretics

445
Liddle syndrome is a genetically inherited form of hypertension characterized by the overactivity of epithelial sodium channels in the nephron, the functional unit of the kidney. This heightened activity leads to increased sodium reabsorption and excessive excretion of potassium. To counteract this, potassium-sparing diuretics such as amiloride are used. They function by blocking these sodium channels, thereby reducing the influx of sodium into the epithelial cells and minimizing the loss of...
445
Kidney Structure01:45

Kidney Structure

68.7K
The kidneys are two large bean-shaped organs located in the upper abdomen. They filter the blood several times a day to remove toxins and rebalance water and electrolytes of the circulatory system via the renal veins. The kidneys receive blood directly from the heart via the renal arteries. These arteries enter the kidney at the hilum, the concave surface of the bean, where they branch and divide into smaller vessels and capillaries.
68.7K
Filtration and Urine Formation01:32

Filtration and Urine Formation

49.4K
The function of the kidneys is to filter, reabsorb, secrete, and excrete. Every day the kidneys filter nearly 180 liters of blood, initially removing water and solutes but ultimately returning nearly all filtrates into circulation with the help of osmoregulatory hormones. This process removes wastes and toxins but is also crucial to maintain water and electrolyte levels. Most of these functions are performed by the tiny but numerous nephrons contained within the kidneys.
49.4K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Development and Validation of an Automated Acute Kidney Injury E-Alert System Integrated with Clinical Decision Support for Hospitalized Patients.

Journal of medical systems·2026
Same author

From Parallel Programming to Bidirectional Crosstalk: The Brain-Kidney Axis in Cardiovascular-Kidney-Metabolic Syndrome.

Antioxidants (Basel, Switzerland)·2026
Same author

Life-Course Programming of Kidney Disease: Roles of Gut Microbiota Dysbiosis and Oxidative Stress.

Antioxidants (Basel, Switzerland)·2026
Same author

Clinical associations during the year before Parkinson's disease diagnosis in Taiwan: a nationwide claims-based case-control study.

Annals of medicine·2026
Same author

Machine learning-based prediction of a high-risk kidney function trajectory class after acute kidney injury.

BMJ health & care informatics·2026
Same author

Life-Course Regulation of Health and Disease by Nitric Oxide: Mechanistic Insights.

Antioxidants (Basel, Switzerland)·2026

相关实验视频

Updated: Jun 3, 2025

In Utero Intra-cardiac Tomato-lectin Injections on Mouse Embryos to Gauge Renal Blood Flow
10:25

In Utero Intra-cardiac Tomato-lectin Injections on Mouse Embryos to Gauge Renal Blood Flow

Published on: February 4, 2015

9.7K

脏编程和高血压:将产前发育与成年期联系起来

You-Lin Tain1,2, Chien-Ning Hsu3,4

  • 1Division of Pediatric Nephrology, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 833, Taiwan.

International journal of molecular sciences
|January 8, 2025
PubMed
概括

早期的生活环境因素可以对脏进行编程,导致高血压. 本综述探讨了为编程高血压的分子途径和重编程干预措施,将重点从传统治疗转移到传统治疗.

关键词:
慢性脏疾病 慢性脏疾病健康和疾病的发展起源 (DOHaD)我们的肠道微生物群.这种高血压,高血压.脏的赋予 脏的赋予氧化氧化的使用方法氧化应激是一种氧化应激.宁血管酶系统

更多相关视频

A Modified Two Kidney One Clip Mouse Model of Renin Regulation in Renal Artery Stenosis
08:21

A Modified Two Kidney One Clip Mouse Model of Renin Regulation in Renal Artery Stenosis

Published on: October 26, 2020

4.6K
5/6th Nephrectomy in Combination with High Salt Diet and Nitric Oxide Synthase Inhibition to Induce Chronic Kidney Disease in the Lewis Rat
08:50

5/6th Nephrectomy in Combination with High Salt Diet and Nitric Oxide Synthase Inhibition to Induce Chronic Kidney Disease in the Lewis Rat

Published on: July 3, 2013

23.5K

相关实验视频

Last Updated: Jun 3, 2025

In Utero Intra-cardiac Tomato-lectin Injections on Mouse Embryos to Gauge Renal Blood Flow
10:25

In Utero Intra-cardiac Tomato-lectin Injections on Mouse Embryos to Gauge Renal Blood Flow

Published on: February 4, 2015

9.7K
A Modified Two Kidney One Clip Mouse Model of Renin Regulation in Renal Artery Stenosis
08:21

A Modified Two Kidney One Clip Mouse Model of Renin Regulation in Renal Artery Stenosis

Published on: October 26, 2020

4.6K
5/6th Nephrectomy in Combination with High Salt Diet and Nitric Oxide Synthase Inhibition to Induce Chronic Kidney Disease in the Lewis Rat
08:50

5/6th Nephrectomy in Combination with High Salt Diet and Nitric Oxide Synthase Inhibition to Induce Chronic Kidney Disease in the Lewis Rat

Published on: July 3, 2013

23.5K

科学领域:

  • 科和心血管研究.
  • 慢性疾病的发展编程 慢性疾病的发展编程

背景情况:

  • 病和高血压之间的联系已经得到了很好的证实,但其在生命早期的发育起源是不太了解的.
  • 怀孕和哺乳期间的环境暴露会影响胎儿脏发育,导致长期的结构和功能变化.
  • 这种"脏编程"是生命后期高血压的潜在前体.

研究的目的:

  • 审查由于早期脏编程导致高血压发展的基础分子机制.
  • 探索临床前重编程干预措施,旨在预防编程高血压.
  • 强调了解脏编程对于未来高血压管理的重要性.

主要方法:

  • 审查临床前研究和关于脏编程和高血压的现有文献.
  • 检查分子通路,包括表观遗传学,氧化应激,氧化氧化物,氨酸-血管酶系统 (RAS),营养感应,肠道微生物群和运输.
  • 识别和分析拟议的重编程策略.

主要成果:

  • 脏编程涉及复杂的分子途径,如表观遗传修饰,氧化应激和RAS激活.
  • 营养感应,肠道微生物群和运输中的干扰也会导致被编程的高血压.
  • 临床前研究表明,各种重编程干预措施可以预防与脏编程相关的高血压.

结论:

  • 早期的脏编程是高血压发展的重要因素.
  • 了解这些分子机制和重编程策略对于预防编程高血压至关重要.
  • 需要将重点转向发育起源和重编程干预措施,而不是传统的高血压治疗.