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Genomics02:02

Genomics

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Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
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Diversity in Cell Signaling Responses01:22

Diversity in Cell Signaling Responses

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The physiological function of a cell and cellular communication are outcomes of a range of extrinsic signals, intracellular signaling pathways, and cellular responses. No two cell types express the same repertoire of signaling components. Receptors are highly selective for their cognate ligands, but once activated, they can alter multiple cellular processes such as DNA transcription, protein synthesis, and metabolic activity. 
Graded and Abrupt Responses
Some signaling systems generate...
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Target Cell Response to Hormones01:22

Target Cell Response to Hormones

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Hormones intricately bind to receptors on the surface or within target cells, initiating a cascade of cellular responses.
Notably, the cellular response can be regulated by altering the number of receptors expressed in the cell. For example, prolonged exposure to elevated hormone levels results in a gradual decline or down-regulation in the number of receptors for that specific hormone on the cell surface. Conversely, in response to low hormone levels, cells may use up-regulation, producing an...
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Proteomics01:33

Proteomics

7.2K
A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term...
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Single-cell Analysis of Immunophenotype and Cytokine Production in Peripheral Whole Blood via Mass Cytometry
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从多种omics方法定义差异性皮质类固醇反应基础.

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概括

皮质类固醇是广泛使用的,但显示出不同的患者反应. 奥米克的方法正在揭示影响治疗疗效和副作用的遗传因素,解决关键的知识差距.

关键词:
皮质类固醇是什么在表观基因组学上,表观基因组学.基因组学就是基因组学.葡萄糖皮质类药物是什么代谢生物组的代谢生物组蛋白质组学 蛋白质组学翻译学 翻译学 翻译学 翻译学

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科学领域:

  • 药物基因组学 药物基因组学
  • 分子医学是分子医学.
  • 遗传学 是一个遗传学.

背景情况:

  • 皮质类固醇是诸如喘和白血病等众多疾病的必要治疗方法.
  • 患者反应和副作用的个体间变化仍然是一个重大的临床挑战.
  • 这些变异的潜在遗传基础尚未完全理解.

研究的目的:

  • 审查最近关于影响皮质类固醇反应的因素的文献.
  • 专注于奥米克在理解遗传变异性方面的作用.
  • 确定需要进一步研究的知识空白在皮质类固醇治疗.

主要方法:

  • 对皮质类固醇反应研究的综合文献综述.
  • 强调基因组,转录组和其他基于奥米克的研究.
  • 分析与治疗疗效和不良反应的个体间变异性相关的数据.

主要成果:

  • 奥米克技术正在开始阐明影响皮质类固醇疗效的遗传因素.
  • 患者反应的变化与遗传倾向有关.
  • 关于精确的遗传影响,仍然存在重大知识差距.

结论:

  • 了解遗传因素对于个性化皮质类固醇治疗至关重要.
  • 为了优化治疗策略,迫切需要进一步的奥米克研究.
  • 解决个体间的变异性将改善患者的治疗结果并减少副作用.