细胞外囊泡和植物晶体,以提高黄素作为BCS第四类药物的生物可用性
Muzn Alkhaldi1, Tehseen Sehra1,2, Soma Sengupta1
1Department of Pharmaceutics and Biopharmaceutics, Philipps-Universität Marburg, Robert-Koch-Str. 4, 35037 Marburg, Germany.
Molecules (Basel, Switzerland)
|January 8, 2025
概括
含有细胞外囊泡 (PCEVs) 的晶体显著增强黄素等难溶药物的皮肤透. 这种新的plantCrystals策略优于传统的细胞外囊泡方法用于局部药物输送.
科学领域:
- 制药科学 制药科学
- 药物运输 药物运输 药物运输
- 纳米技术纳米技术
背景情况:
- 活性药物成分 (API) 的水溶性较差限制了皮肤药物递送的有效性.
- 生物制药分类系统 (BCS) 第四类药物,如黄素,在局部应用方面存在重大制剂挑战.
研究的目的:
- 为了增强黄素的皮肤透,这是BCS第四类药物.
- 为了比较含有细胞外囊泡 (PCEVs) 的植物晶体与用于局部药物递送的传统细胞外囊泡 (EVs) 的疗效.
主要方法:
- 使用古典方法隔离电动汽车.
- 通过大豆分散的珠子磨削来制备PCEV.
- 用PCEV (含库尔库的PCEV和添加库尔库的PCEV) 和EVs配制库尔库.
- 物理化学性质的表征和皮肤透的评估使用皮肤动力学和活体猪耳朵模型.
主要成果:
- 与添加黄素的PCEV和添加黄素的EV相比,含黄素的PCEV显示出明显更高的皮肤透效率 (1.5倍和2.7倍的增加).
- 含有黄素的PCEV实现了更高的透深度.
- 通过含有黄素的电动汽车输送的黄素主要留在角层中.
结论:
- 与传统的EV方法相比,PlantCrystals策略,特别是通过珠子研磨,是一种更有效的方法,可以提高BCS IV类药物的局部输送,如黄素.
- PCEVs为改善疏水化合物的皮肤传递提供了一个有希望的平台.
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