用于聚合物载体的聚合化基抗生素:具有克洛克萨西林和安皮西林联合负载的系统
Shadi Keihankhadiv1, Dorota Neugebauer1
1Department of Physical Chemistry and Technology of Polymers, Faculty of Chemistry, Silesian University of Technology, 44-100 Gliwice, Poland.
Molecules (Basel, Switzerland)
|January 8, 2025
概括
新的基于胆的聚合物有效地提供单抗和双抗生素,如克洛克萨西林和安皮西林. 这些药物输送系统显示了高药物负载和受控释放,为传统的抗生素输送方法提供了有希望的替代方案.
科学领域:
- 聚合物化学 聚合物化学
- 材料科学 材料科学 材料科学
- 制药科学 制药科学
背景情况:
- 传统的抗生素输送系统在药物加载和控制释放方面面临挑战.
- 开发先进的药物输送系统 (DDS) 对于提高治疗疗效和患者服药性至关重要.
- 线性胆聚合物为设计功能DDS提供了一个多功能平台.
研究的目的:
- 设计和合成使用线性胆聚合物的单种和双种药物递送系统 (DDS).
- 为了结合药物功能化的单体,特别是[2-(methacryloyloxy) ethyl]trimethylammonium (TMAMA),与抗生素对手克洛沙 (CLX) 或安培 (AMP).
- 评估开发的基于聚合物的DDS的特性,药物负载和体外释放概况.
主要方法:
- 控制的TMAMA与CLX的聚合或与TMAMA和AMP的共聚合,以产生线性胆聚合物.
- 聚合物组成的特征,聚合度 (DPn) 和药物离子含量.
- 在水溶液中形成聚合物纳米粒子并测量粒子大小.
- 在体外药物释放研究中,使用酸盐缓冲盐水 (PBS) 模拟生理条件.
主要成果:
- 精确定义的线性共聚合物,具有可调的TMAMA含量 (38-93mol). %) 已成功合成.
- 聚合物组合被单体比率和总转换 (40-75%) 控制,产生160-300的DPn.
- 聚合物颗粒在274-380 nm (CLX-) 和288-348 nm (CLX-/AMP-) 之间.
- 观察到高药物释放效率:58-76%的CLX-单一系统和91-100% (CLX-) 和97-100% (AMP-) 双系统.
- 实现了令人满意的药物加载含量和 (共释放),表现优于传统系统.
结论:
- 基于胆的聚合物DDS为单抗和双抗生素输送提供了有效的策略.
- 开发的系统展示了受控释放动力学和高药物负载能力.
- 与传统方法相比,这些聚合物DDS代表了增强抗生素输送的有希望的替代方案.
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