关于制备抗凝剂BAY243333434的制备过程的研究
Yanqun Zeng1, Guodong Cen1, Guanglin Zhou1
1Chengdu Shibeikang Biomedical Technlogy Co., Ltd., 26-1-2, No.2 Tianyu Road, Chendu Gaoxin West District, Chengdu 611700, China.
Molecules (Basel, Switzerland)
|January 8, 2025
概括
为BAY2433334开发了一种新的工业合成方法,绕过了现有的专利. 这种高效的工艺可以产生高纯度的BAY2433334与最小的杂质,消除了需要性分辨率和降低成本.
科学领域:
- 化学合成 化学合成
- 过程化学 过程化学
- 制药制造业 制药制造业 制药制造业
背景情况:
- BAY2433334是一种重要的药物化合物.
- 对于BAY2433334的现有合成路径,受到专利限制.
- 工业规模的生产需要具有成本效益和高效的方法.
研究的目的:
- 开发一种新的,未受专利限制的工业生产工艺BAY2433334.
- 建立一个具有成本效益和可扩展的合成路线.
- 为了达到高的产品纯度和产量.
主要方法:
- 合成从 (2R) - 2 - 氨基黄油酸开始.
- 关键反应包括化,二化,凝结,脱乙烯化,激活和三obu反应.
- 该工艺旨在实现操作简单,并使用易于获得的原材料.
主要成果:
- 已经成功开发了BAY2433334的新工业工艺路线.
- 该工艺产生的高纯度BAY2433334具有高的N-基化产品/O-基化产品比率 (>35-45:1).
- 体过剩 (ee) 值超过99%,避免了需要体解析的需要,并大大降低了成本.
结论:
- 开发的工艺为工业生产提供了一个可行的,无需专利的替代方案. BAY2433334
- 这种方法简单,具有成本效益,并产生高质量的产品.
- 实现的高反体纯度简化了下游加工,降低了整体制造成本.
相关概念视频
Anticoagulant Drugs: Low-Molecular-Weight Heparins
607
Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
607
Coagulation
264
Colloidal solids are solid particles suspended in solution. They are usually negatively charged, attracting a compact primary layer of positively charged ions, which attract more counterions to form an electrical double layer. Electrostatic repulsion between the charged double layers prevents the particles from colliding, stabilizing the colloids. These solids are often undesirable because they can contain toxins that are difficult to remove. Coagulation is a technique that helps aggregate and...
264
Sample Preparation for Analysis: Overview
186
Sample preparation is an essential step in the analytical process. It involves preparing a sample so that it can be analyzed accurately. The goal is to extract the analyte, the substance you want to measure, from the sample while removing any components that may interfere with the analysis. Sample preparation techniques vary depending on the physical state of the sample.
Bulk or large solid samples are typically reduced in size using grinding, crushing, or milling techniques to increase the...
Bulk or large solid samples are typically reduced in size using grinding, crushing, or milling techniques to increase the...
186


