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空心纤维微反应器与数字双胞胎相结合,以优化抗菌评估过程

Kazuhiro Noda¹, Toshihiro Kasama¹, Marie Shinohara²

¹Bioengineering, School of Engineering, The University of Tokyo, Tokyo 113-8656, Japan.

|January 8, 2025

概括

针对抗微生物耐药性研究的新型空心纤维微反应器减少了药物和媒介的使用. 它的数字双胞胎控制方法确保了精确的药物度稳定性,改善了体外药物动力学分析.

科学领域:

药理学和微生物学
生物技术和生物工程生物技术和生物工程

背景情况:

空纤维感染模型 (HFIM) 对于体外抗菌素耐药性评估和体内药理动力学 (PK) 复制至关重要.
传统的HFIM需要大量的培养基和药物,这带来了经济和后勤方面的挑战.

研究的目的:

开发一个小型的空心纤维微反应器,与HFIM功能集成,以减少资源消耗.
实施一种新的数字双胞胎控制策略,用于微反应器内的精确药物度管理.

主要方法:

开发一个集成HFIM能力的空心纤维微反应器,显著减少额外毛细血管空间体积.
构建和应用数字双胞胎模型,用于实时监测和控制药物度.
模拟药物破坏,以测试控制系统的稳定性.

主要成果:

集成微反应器将额外毛细血管空间的体积减少到传统HFIM的1/10以下.
数字双胞胎控制方法保持了药物度在10%的误差范围内,即使在模拟药物降解的情况下.
在15分钟内,在毛细管内和毛细管外空间都能达到稳定的药物度.

结论:

开发的空心纤维微反应器为抗菌素耐药性研究提供了一个资源高效的平台.
数字双胞胎控制方法使药物度保持精确和稳定,提高了 in vitro PK 概况复制的可靠性.
这一综合系统推进了体外抗菌药物评估和PK建模.

关键词:

抗微生物耐药性抗微生物耐药性流体学是一个流体学.迷你化的迷你化数字模拟的数字模拟.

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