肠道微生物组的参与和调节在治疗复发性尿路感染的管理
Mattia Brigida1, Angela Saviano2, Carmine Petruzziello3
1Gastroenterology Department, Policlinico Tor Vergata, 00133 Rome, Italy.
Pathogens (Basel, Switzerland)
|January 8, 2025
概括
尿路感染 (UTI) 与肠道健康有关. 肠道功能障碍,特别是大肠杆菌的过度生长,增加了尿路感染的风险和抗生素耐药性,这表明尿路感染可能是与肠道有关的疾病.
科学领域:
- 微生物学 微生物学
- 传染性疾病 传染性疾病
- 胃肠病学 胃肠病学
背景情况:
- 尿路感染 (UTI) 是一种常见的细菌感染,发病率很高,特别是在女性中.
- 引起尿路感染的病原体通常起源于肠道,并且在尿路感染的发病过程中越来越多地认识到肠道失调.
- 最近的诊断技术的进步改善了对尿道微生物群落的理解.
研究的目的:
- 审查最近关于肠-尿道微生物组关联的研究.
- 总结肠道和尿道微生物相互作用对尿路感染发展的影响.
- 探索新的治疗策略,包括益生菌,用于尿路感染.
主要方法:
- 关于肠道微生物群,尿道微生物群和尿路感染的最新科学文献的综述.
- 分析诊断技术,如定量尿液培养和下一代测序.
- 综合当前关于微生物社区相互作用的知识,以及它们在尿路感染病原发生中的作用.
主要成果:
- 肠道功能障碍是导致尿路感染的重要因素.
- 来自肠道的大肠杆菌 (大肠杆菌) 是主要的尿路感染病原体;其过度生长是危险因素.
- 肠道微生物群含有抗生素耐药性基因,影响尿路感染治疗.
- 泌尿道拥有自己的微生物群,挑战了无菌环境的概念.
结论:
- 尿路感染应该被视为可能与肠道相关的疾病,而不仅仅是尿路疾病.
- 了解肠道和尿道微生物组之间的相互作用为治疗提供了新的途径.
- 益生菌显示出作为治疗治疗尿路感染的治疗选择的希望.
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