追踪2023年在意大利北部发生的1型登革热病例的起源,传播和分子演变
Greta Romano1, Guglielmo Ferrari1, Antonino Maria Guglielmo Pitrolo1
1Microbiology and Virology Department, Fondazione IRCCS Policlinico San Matteo, 27100 Pavia, Italy.
Pathogens (Basel, Switzerland)
|January 8, 2025
概括
在意大利北部检测到1型登革热病毒 (DENV-1),与南美菌株有关. 这凸显了由于蚊子Aedes albopictus的传播,需要加强温带地区的监测.
科学领域:
- 病毒学 病毒学
- 流行病学 流行病学
- 基因组学就是基因组学.
背景情况:
- 全球登革热病毒 (DENV) 发病率正在上升,非热带地区的感染率增加.
- 能够携带DENV的蚊子Aedes albopictus正在扩散到较冷的气候地区.
- 温带地区本土登革热爆发是一个日益严重的公共卫生问题.
研究的目的:
- 调查来自意大利北部伦巴第地区爆发的DENV-1菌株的分子进化和地理起源.
- 评估当地Aedes albopictus种群在DENV-1传播中的作用.
- 了解DENV-1的引入途径和本地传播动态.
主要方法:
- 从临床样本中恢复DENV-1序列的元基因组测序.
- 使用全球DENV-1序列数据集进行了家族遗传学和贝叶斯分析.
- 在受影响地区对Aedes albopictus进行昆虫学监测.
主要成果:
- 意大利DENV-1菌株与南美菌株 (基因型V,亚型D) 聚集于2020-2023.
- 估计平均进化速率为8.234 × 10^-4替代/地点/年.
- 最新的共同祖先 (tMRCA) 的时间估计在1972年 (1968-1976).
结论:
- 伦巴第DENV-1疫情很可能是从南美洲引入的,随后在当地传播.
- 基因组监测对于监测新受影响地区的病毒传播和演变至关重要.
- 加强分子和昆虫学监测对于早期检测和对温带地区本土登革热的反应至关重要.
相关概念视频
Viral Mutations
32.1K
A mutation is a change in the sequence of bases of DNA or RNA in a genome. Some mutations occur during replication of the genome due to errors made by the polymerase enzymes that replicate DNA or RNA. Unlike DNA polymerase, RNA polymerase is prone to errors because it is not capable of “proofreading” its work. Viruses with RNA-based genomes, like HIV, therefore accrue mutations faster than viruses with DNA-based genomes. Because mutation and recombination provide the raw material...
32.1K
Steps in Outbreak Investigation
105
In the ever-evolving field of public health, statistical analysis serves as a cornerstone for understanding and managing disease outbreaks. By leveraging various statistical tools, health professionals can predict potential outbreaks, analyze ongoing situations, and devise effective responses to mitigate impact. For that to happen, there are a few possible stages of the analysis:
105
Viral Recombination
23.2K
Cells are sometimes infected by more than one virus at once. When two viruses disassemble to expose their genomes for replication in the same cell, similar regions of their genomes can pair together and exchange sequences in a process called recombination. Alternatively, viruses with segmented genomes can swap segments in a process called reassortment.
23.2K
Infection
7.6K
When a pathogen enters the body and reproduces, it can cause an infection, damage body cells, and cause illness symptoms that eventually lead to disease. Therefore, its prevention requires breaking the chain of infection.
The chain begins with pathogens: bacteria, viruses, fungi, prions, or parasites such as protozoa helminths. These can be present on the skin as transient or resident flora, or they can be acquired from the environment. Identifying and treating the type of infection and...
The chain begins with pathogens: bacteria, viruses, fungi, prions, or parasites such as protozoa helminths. These can be present on the skin as transient or resident flora, or they can be acquired from the environment. Identifying and treating the type of infection and...
7.6K


