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来自葡萄藤叶和的先进组合系统增强了抗氧化剂的皮肤传递和纤维细胞功能

Sophia Athanasopoulou¹, Eleni Spanidi¹, Eleni Panagiotidou¹

¹Research and Development Department, APIVITA SA, Industrial Park Markopoulo Mesogaias, 19003 Athens, Greece.

Pharmaceuticals (Basel, Switzerland)

|January 8, 2025

概括

来自葡萄树叶和的多被封装在脂质体和环氧中. 这种新型的输送系统增强了皮肤纤维细胞的抗氧化和细胞外基质保护作用,促进了原蛋白和弹性素的合成.

科学领域:

化品科学化品科学
生物技术是生物技术.
皮肤病学皮肤病学

背景情况:

葡萄树叶是一种葡萄酒行业的副产品,含有有价值的多.
聚醇被提取和封装使用一种新型的脂质体-环素输送系统.
该系统与的多相结合,可控制抗氧化剂的释放.

研究的目的:

从葡萄树叶和蜂多中开发一种新的生物活性成分.
评估封装聚醇的抗氧化和细胞外基质 (ECM) 保护作用.
评估皮肤纤维细胞 (NHDF) 的疗效.

主要方法:

聚烯提取和封装在脂质体和环氧中.
通过Folin-Ciocalteu和DPPH试验评估的抗氧化能力.
在NHDF体外研究:生命力,迁移,基因表达,原蛋白,弹性蛋白和原酶测定.

主要成果:

组合输送系统促进了原蛋白和弹性蛋白的合成和沉积在NHDF中.
观察到显著的原酶活性抑制,表明预防原降解.
该系统在正常和压力条件下证明了抗氧化和ECM保护作用.

结论:

包装在脂质体-环氧化中的聚醇代表了一种新型的生物活性成分.
由于其抗氧化和ECM保护性质,该复合物显示出对皮肤应用的有前途潜力.
这项技术为葡萄酒行业副产品的化品用途提供了可持续的使用.

关键词:

原蛋白是一种原蛋白.弹性弹性纤维是一种弹性.聚醇是一种多醇.皮肤输送系统的皮肤输送系统.

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