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Updated: Jun 3, 2025

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通过使用生理学基础的药理动力学模型,预测Spatholobi caulis中活性成分的药理动力学

Xiaoyan Liu1, Ruihu Du1, Tao Zhang1

  • 1Department of Toxicology, School of Public Health, Peking University, Beijing 100191, China.

Pharmaceuticals (Basel, Switzerland)
|January 8, 2025
PubMed
概括

基于生理学的药理动力学 (PBPK) 模型被开发为Spatholobi Caulis (SPC) 在老鼠中的成分. 这些经过验证的模型准确地预测了大鼠的药理动力学,并将其推断为人类的药物暴露,以确保安全的临床使用.

关键词:
超值推算的方法通过口服进行口服管理.药物动力学特征 药物动力学特征基于生理学的药物动力学模型.

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