低剂量口服生改善了的每日症状得分
Charles W Emala1, Tarnjot K Saroya2, Yuqi Miao3
1Department of Anesthesiology, Columbia University Vagelos College of Physicians and Surgeons, 628 W. 168th St. PH 505 Center, New York, NY 10032, USA.
Pharmaceuticals (Basel, Switzerland)
|January 8, 2025
概括
生补充剂可以改善轻度至中度喘的成年人的喘症状控制. 这项研究发现,每天摄入生可以改善主观喘控制和调节炎症标志物,这表明它有可能成为一种新的治疗方法.
科学领域:
- 呼吸系统医学 呼吸系统医学
- 免疫学 免疫学 免疫学
- 药理学 药理学是指药理学的学科.
背景情况:
- 许多患有喘的人经历不良控制的症状,尽管常规疗法.
- 包括生在内的食补充剂经常被喘患者用于寻求症状缓解.
- 生改善喘控制的功效在很大程度上仍未得到证实.
研究的目的:
- 研究低剂量口服生补充剂对轻度至中度喘患者喘控制的影响.
- 评估喘控制的主观和客观测量.
主要方法:
- 这是一项为期2个月的随机化,安慰剂控制,双盲研究,涉及32名轻度至中度喘患者.
- 参与者接受低剂量 (每天两次1克) 的生补充剂,同时继续标准喘治疗.
- 主要结局包括甲胆挑战和氧化 (FeNO) 的分量分泌;次要结局评估了通过ACT控制喘,症状回忆,AQLQ,血液中乙氨基基基和细胞因子.
主要成果:
- 口服生并没有显著改变FeNO度或血中乙氨基酸细胞的数量.
- 三种不同的喘症状控制措施显示,生补充剂的28日后出现改善.
- 与喘相关的血清细胞因子,特别是IL-13和IL-17A,通过口服生摄入来调节.
结论:
- 这项研究提供了第一个证据,即每天少量服用生可以增强喘症状控制和减少人类的炎症.
- 这些发现表明生的潜力作为一种新的治疗喘的药物.
- 需要进一步研究更高剂量的生和特定的喘内型,以证实这些结果并探索治疗应用.
相关概念视频
01:29Asthma-I: Introduction
2.6K
Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
2.6K
01:25Antiasthma Drugs: Inhaled Corticosteroids and Glucocorticoids
217
Inhaled corticosteroids (ICS) are anti-inflammatory drugs used primarily in treating persistent asthma and providing long-term maintenance. They target the bronchial mucosa, the lining of the airways, to control inflammation, a critical factor in asthma progression and exacerbation.
ICS work through a multifaceted mechanism of action. They suppress the inflammatory response caused by the proliferation of TH cells. They also reduce the transcription of the IL-2 gene, which is involved in the...
ICS work through a multifaceted mechanism of action. They suppress the inflammatory response caused by the proliferation of TH cells. They also reduce the transcription of the IL-2 gene, which is involved in the...
217
01:25Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs
236
Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
236
01:30Asthma-IV: Diagnostic and Management
2.5K
The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
2.5K
01:25Antiasthma Drugs: β2-Adrenoceptor Agonists
231
Bronchodilators are critical in managing asthma, a chronic respiratory condition characterized by airway constriction due to inflammation and hyper-reactivity. Specifically, bronchodilators ease this constriction by relaxing the bronchial muscles, facilitating easier breathing.
One class of bronchodilators includes β2-adrenoceptor agonists. These agents target the β2-adrenoceptors located on bronchial smooth muscle cells. By stimulating these receptors, β2-agonists induce...
One class of bronchodilators includes β2-adrenoceptor agonists. These agents target the β2-adrenoceptors located on bronchial smooth muscle cells. By stimulating these receptors, β2-agonists induce...
231
01:24Asthma-III: Symptoms and Complications
2.5K
Asthma, a common chronic respiratory condition, is classified considering the frequency and severity of symptoms alongside lung function impairment. Understanding this classification is essential for appropriate treatment and management. Here's a detailed look at the classification of asthma and its clinical features and complications:
Classification of Asthma
Classification of Asthma
2.5K