狗麻醉方面的进展:基于生理学的药动力学建模,用于预测肝功能障碍的狗中普罗波的血概况

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Updated: Jun 3, 2025

Standardization and Maintenance of 3D Canine Hepatic and Intestinal Organoid Cultures for Use in Biomedical Research
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Standardization and Maintenance of 3D Canine Hepatic and Intestinal Organoid Cultures for Use in Biomedical Research

Published on: January 31, 2022

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Lucas Wamser Fonseca Gonzaga1, Beatriz Monte Egito1, João Bosco Costa Coelho1

  • 1Department of Veterinary Medicine, Universidade Federal de Lavras, Lavras 37200-900, MG, Brazil.

Pharmaceuticals (Basel, Switzerland)
|January 8, 2025
PubMed
概括

这项研究开发了一种基于生理学的药理动力学 (PBPK) 模型,以优化健康狗和肝功能障碍的狗的普罗波福尔剂量. 该PBPK模型准确地预测了药物度,确保了安全有效的麻醉.

关键词:
模型 PK PK 模型 PK 模型剂量个性化剂量个性化精密麻醉精确麻醉

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