肺癌中的肺微生物组:系统性审查
Sergiu-Remus Lucaciu1, Bianca Domokos1, Ruxandra Puiu1
1Department of Pneumology, Iuliu Hațieganu University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania.
Microorganisms
|January 8, 2025
概括
支气管肺癌中的肺微生物组缺乏一致的细菌模式. 占主导地位的类和属在不同研究中存在显著差异,阻碍了诊断潜力.
科学领域:
- 微生物学 微生物学
- 在瘤学瘤学.
- 肺部病理学 肺部病理学
背景情况:
- 肺部微生物组在支气管肺癌中的作用正在调查中.
- 之前使用16S rRNA测序的研究表明,在肺癌中,细菌种群的多样性可变.
- 缺乏关于肺部微生物组在支气管肺癌中的百分比组成的全面总结.
研究的目的:
- 在支气管肺癌中识别占主导地位的细菌种群 (系和属).
- 为了确定是否存在一个比例的微生物组模式来诊断支气管肺癌.
- 系统地审查有关肺癌肺部微生物组的现有文献.
主要方法:
- 对MEDLINE,Embase和Web of Science数据库进行系统审查.
- 包括使用支气管支气管洗样本对支气管肺癌肺部微生物组的研究.
- 独立的数据提取,重点关注类和属级别的百分比组成.
主要成果:
- 九项研究符合纳入标准.
- 在研究中观察到细菌类和属的显著异质性.
- 发现了Firmicutes属和Streptococcus和Veillonella属的一致百分比,但变化很大.
- 参与者标准,样本采集和数据处理的差异导致了异质性.
结论:
- 在支气管肺癌中,没有在属或属层面确定肺微生物组的一致百分比模式.
- 特定细菌种群的占主导地位在患者队列之间有所不同.
- 观察到的变异性阻止了基于肺微生物组的支气管肺癌可靠诊断模式的建立.
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