人类鼻腔微生物组:在马耳他SARS-CoV-2大流行期间的视角研究
David Pinzauti1, Simon De Jaegher1, Maria D'Aguanno1
1The BioArte Ltd., Life Science Park, Triq San Giljan, 3000 San Gwann, Malta.
Microorganisms
|January 8, 2025
概括
COVID-19 感染会改变鼻腔微生物组,减少微生物多样性,增加机会性细菌. 呼吸道微生物组的这些变化可能会影响疾病的严重程度和对共感染的易感性.
科学领域:
- 微生物学 微生物学
- 传染性疾病 传染性疾病
- 基因组学就是基因组学.
背景情况:
- 人的呼吸道内有复杂的微生物群,对健康和对病原体的防御至关重要.
- 呼吸道病毒感染,包括SARS-CoV-2,可以破坏这种微妙的微生物平衡,可能导致二次细菌感染和疾病严重程度的增加.
- 了解这些变化对于开发新的治疗策略至关重要.
研究的目的:
- 研究与未感染个体相比,感染SARS-CoV-2的患者鼻腔微生物群的组成差异.
- 为了确定在SARS-CoV-2感染期间丰度变化的特定细菌物种.
主要方法:
- 在马耳他SARS-CoV-2大流行期间,从COVID-19阳性 (n=85) 和阴性 (n=94) 患者收集了鼻.
- 使用牛津纳米孔技术进行了全长16S rRNA基因测序,以分析鼻腔微生物群的组成.
- 进行了生物信息分析,以比较α和β多样性,并确定微生物种群的差异丰度.
主要成果:
- 在COVID-19阳性和阴性组之间观察到鼻子微生物群的α和β多样性的显著差异.
- 在COVID-19阳性队列中发现了微生物丰富度和均性减少的趋势.
- 在感染SARS-CoV-2的患者中发现了机会性鼻腔病原体的大量增加,包括*Citrobacter koseri*,*Dolosigranulum pigrum*,*Haemophilus influenzae*,*Klebsiella pneumoniae*和*Moraxella catarrhalis*.
结论:
- SARS-CoV-2 感染显著改变了鼻腔微生物群的组成,其特点是减少多样性和机会性细菌的增加.
- 这些微生物组的变化可能会导致疾病的发病,严重程度和对共感染的易感性.
- 识别这些微生物驱动的变化可能会导致新的预后标志物和COVID-19的治疗干预措施.
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