感染不同SARS-CoV-2变种的患者心脏损伤令人担忧
Francesco Robert Burkert1, Martina Oberhollenzer1, Daniela Kresse1
1Department of Internal Medicine II, Medical University of Innsbruck, Anichstraße 35, 6020 Innsbruck, Austria.
Microorganisms
|January 8, 2025
概括
与野生型/阿尔法变种相比,COVID-19的Omicron变种与更高的心脏生物标志物水平有关,特别是高灵敏度的Troponin-T和NT-proBNP. 尽管心脏病发病率增加,但两组患者的住院死亡率相似.
科学领域:
- 心脏病学 心脏病学
- 传染性疾病 传染性疾病
- 病毒学 病毒学
背景情况:
- 冠状病毒疾病2019 (COVID-19) 引起关注的变种 (VOC) 对器官系统产生不同的影响.
- 之前的研究表明COVID-19可能涉及心脏,但不同VOC之间的比较有限.
研究的目的:
- 为了比较野生型/阿尔法 (wt/Alpha) VOC感染的住院患者的心脏生物标志物和临床结果,与Omicron VOC相比.
- 调查不同COVID-19 VOCs的心脏生物标志物水平和临床结果之间的关联.
主要方法:
- 进行了单中心回顾性队列分析.
- 感染 wt/Alpha VOC (n=428) 的住院患者与感染 Omicron VOC (n=117) 的患者进行了比较.
- 分析了最大的高灵敏度Troponin-T (hs-TnT) 和N-终端前激素的大脑 natriuretic (NT-proBNP) 的水平.
主要成果:
- 与wt/Alpha队列相比,Omicron队列的最大中位数hs-TnT (27.8 ng/L与12.8 ng/L) 和NT-proBNP (825 ng/L与256 ng/L) 水平显著更高 (p <0.001).
- 在Omicron组中,即使在没有先前存在心血管疾病的年轻患者中也观察到心脏生物标志物的增加.
- 住院死亡率相似 (7.7%的Omicron与12.7%的重量/阿尔法;p = 0.132),但更多的重量/阿尔法患者需要重症监护入院 (22.2%与12%;p = 0.014).
结论:
- 与Omicron VOC感染的住院患者表现出显著更高的心脏生物标志物水平 (hs-TnT,NT-proBNP),表明心脏参与程度较高.
- 尽管Omicron队列中的心脏生物标志物水平增加,但两组患者的住院死亡率相似.
- 增加的心脏生物标志物与高风险的死亡率和ICU入院相关,无论是体重/阿尔法和Omicron感染的患者.
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