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肠道微生物组合的变化与阻塞性睡眠呼吸暂停儿童的情绪痛苦变化有关

Chung-Guei Huang^1,2, Wan-Ni Lin^3,4, Li-Jen Hsin^3,4

¹Department of Laboratory Medicine, Linkou Main Branch, Chang Gung Memorial Hospital, Taoyuan 33305, Taiwan.

|January 8, 2025

概括

儿科阻塞性睡眠呼吸暂停 (OSA) 与情绪困扰 (ED) 和改变的肠道细菌有关. 治疗改善了ED和肠道微生物群的多样性,这表明针对微生物群的治疗可以帮助患有OSA的儿童.

科学领域:

微生物组-肠-大脑轴研究
儿科睡眠药物儿童睡眠药物
情绪和行为健康情绪和行为健康

背景情况:

肠道微生物群通过微生物群-肠道-大脑轴影响情绪和行为反应.
儿科阻塞性睡眠呼吸暂停 (OSA) 与情绪困扰 (ED) 有关.

研究的目的:

调查小儿OSA,ED和肠道微生物组变化之间的关系.
评估在OSA治疗前后ED和肠道微生物组的变化.

主要方法:

66名患有OSA的儿童接受了多睡眠学和腺切除术.
用OSA-18问卷进行了情绪困扰的评估.
肠道微生物组的多样性和组成在治疗前和后被分析.

主要成果:

患有高ED的儿童表现出肠道微生物组α多样性的减少 (香农指数) 和β多样性的增加.
在治疗后,OSA症状,ED和肠道微生物群α多样性的显著改善被观察到.
特定的细菌变化 (例如,Veillonella,Bifidobacterium) 和心率变化指标与ED变化有关.

结论:

肠道微生物组在小儿OSA的情绪和行为症状中起着至关重要的作用.
针对微生物组的干预措施可以提供一种补充传统治疗方法的方法,以减少OSA儿童的ED.
需要进一步的研究来探索这些联系和治疗潜力.

关键词:

腺腺切除术是什么孩子们的孩子们的孩子们的孩子们.饮食特征饮食特征教育咨询教育咨询教育咨询情绪上的压力情绪上的压力我们的肠道微生物组.阻塞性睡眠呼吸暂停症是什么睡眠的心率睡眠的心率

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