主体长非编码RNA作为神经细菌与主体相互作用的关键参与者
Stephen K Kotey1,2, Xuejuan Tan1,2, Audrey L Kinser1,2
1Department of Biochemistry and Molecular Biology, Oklahoma State University, Stillwater, OK 74078, USA.
Microorganisms
|January 8, 2025
概括
主体长非编码RNAs (lncRNAs) 是细胞对菌根菌感染反应的关键调节者. 了解这些lncRNA为新的诊断生物标志物和结核病和NTM感染的宿主导疗法提供了潜力.
科学领域:
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
- 遗传学 是一个遗传学.
背景情况:
- 菌根菌感染,包括结核病 (TB) 和非结核菌 (NTM) 感染,对全球健康构成重大挑战.
- 有效的诊断和治疗需要对宿主-病原体相互作用有深刻的了解.
- 主体长非编码RNAs (lncRNAs) 越来越被认为是细胞防御机制对细菌病原体的关键调节者.
研究的目的:
- 审查当前关于宿主 lncRNAs 在真菌细菌感染中的作用的知识.
- 探索宿主 lncRNA 和诸如 * Mycobacterium 结核病 * 和 NTMs 这样的病原体之间的复杂关系.
- 突出 lncRNAs 作为诊断生物标记物和治疗点的潜力.
主要方法:
- 关于在真菌细菌感染中调查宿主 lncRNA 的研究的文献综述.
- 分析lncRNAs在调节细胞反应中的作用,特别是在巨细胞中.
- 综合证据,将特定的lncRNA与疾病病原性联系起来.
主要成果:
- 宿主 lncRNAs 是宿主细胞内的细胞反应的关键调节者,特别是巨细胞,在菌根菌感染期间.
- 特定的lncRNAs参与了结核病和NTM感染的发病.
- 有证据表明 lncRNAs 影响了菌根菌的细胞内生存.
结论:
- 宿主 lncRNAs 在宿主对菌根菌感染的反应中发挥着重要作用.
- lncRNAs代表了开发新型宿主导疗法的有希望的目标.
- 特定宿主 lncRNAs 具有作为结核病和其他真菌菌病的诊断生物标志物的潜力.
相关概念视频
Types of RNA
63.2K
Overview
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in the regulation of gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA...
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in the regulation of gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA...
63.2K
lncRNA - Long Non-coding RNAs
8.5K
In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
8.5K
Riboswitches
8.0K
Riboswitches are non-coding mRNA domains that regulate the transcription and translation of downstream genes without the help of proteins. Riboswitches bind directly to a metabolite and can form unique stem-loop or hairpin structures in response to the amount of the metabolite present. They have two distinct regions – a metabolite-binding aptamer and an expression platform.
The aptamer has high specificity for a particular metabolite which allows riboswitches to specifically regulate...
The aptamer has high specificity for a particular metabolite which allows riboswitches to specifically regulate...
8.0K
MicroRNAs
21.2K
MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After...
21.2K
Bacterial RNA Polymerase
28.6K
Unlike eukaryotes, bacteria use a single RNA Polymerase (RNAP) to transcribe all genes. The different subunits of bacterial RNAPhave distinct functions. The multisubunit structure of the bacterial RNAP helps the enzyme to maintain catalytic function, facilitate assembly, interact with DNA and RNA, and self-regulate its activity.
In most genes, the transcription site is a single base present upstream of the coding sequence. Though RNAP is a catalytically efficient enzyme, it does not recognize...
In most genes, the transcription site is a single base present upstream of the coding sequence. Though RNAP is a catalytically efficient enzyme, it does not recognize...
28.6K
Transcription Attenuation in Prokaryotes
15.1K
Transcriptional attenuation occurs when RNA transcription is prematurely terminated due to the formation of a terminator mRNA hairpin structure. Bacteria use these hairpins to regulate the transcription process and control the synthesis of several amino acids including histidine, lysine, threonine, and phenylalanine. Transcription attenuation takes place in the non-coding regions of mRNA.
There are several different mechanisms used to attenuate transcription. In ribosome mediated...
There are several different mechanisms used to attenuate transcription. In ribosome mediated...
15.1K


