烯胺暴露和心血管风险:系统性审查
Diana María Mérida1,2,3, Jimena Rey-García4, Belén Moreno-Franco5,6,7
1Department of Preventive Medicine and Public Health, School of Medicine, Universidad Autónoma de Madrid, 28029 Madrid, Spain.
Nutrients
|January 8, 2025
概括
从食物中接触到烯胺可能会增加心血管死亡风险,但其代谢物甘胺与肥胖和高血压等不良因素有关. 需要进一步的研究.
科学领域:
- 毒理学 毒理学 毒理学
- 心血管健康 心血管健康
- 营养科学 营养科学
背景情况:
- 烯胺是一种因高温而造成的食品污染物.
- 饮食摄入是非吸烟者的主要暴露来源.
- 烯胺对人类的心脏毒性作用尚不清楚.
研究的目的:
- 评估饮食中的烯胺暴露与心血管风险之间的关联.
- 研究烯胺代谢物在心血管健康中的作用.
主要方法:
- 在四个数据库中进行全面的文献搜索.
- 包括28项研究,主要是横截面设计.
- 使用乔安娜·布里格斯研究所工具进行偏见风险评估.
主要成果:
- 较高的烯胺暴露与心血管死亡率的增加有关.
- 烯胺和葡萄糖/脂质水平,糖尿病,肥胖和代谢综合征之间的反作用.
- 甘胺 (代谢物) 与葡萄糖,脂质,血压和肥胖的升高有关.
结论:
- 烯胺的心血管作用可能由其代谢物甘胺胺 (glycidamide) 介导.
- 需要进一步的研究才能充分了解烯胺对心血管健康的影响.
- 公共卫生工作应专注于减轻暴露和提高认识.
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