循环放缓:背面面向太阳向代谢功能障碍相关的性肝病 (MASLD) 发展
1Gastroenterology Department, Hospital de Vila Franca de Xira, 2600-009 Vila Franca de Xira, Portugal.
Nutrients
|January 8, 2025
概括
现代生活方式扰乱了自然的昼夜节律,导致代谢功能障碍和代谢功能障碍相关的脂肪性肝病 (MASLD) 和癌症等疾病. 恢复昼夜平衡对于代谢健康至关重要.
科学领域:
- 时间生物学 时间生物学
- 代谢健康 代谢健康
- 肝病学 肝病学是一种肝病学.
背景情况:
- 人类进化了与地球24小时光暗周期一致的昼夜节律,影响了新陈代谢和能量恒温.
- 现代生活方式的变化导致了广泛的昼夜干扰,影响睡眠和饮食模式.
- 这种错位越来越多地与代谢障碍有关,包括肥胖,代谢综合征和代谢功能障碍相关的脂肪性肝病 (MASLD).
研究的目的:
- 审查昼夜干扰对新陈代谢的影响.
- 探索食物和睡眠周期中断在MASLD病变发生中的特定作用.
- 为了检查昼夜干扰,MASLD和肝细胞癌的发展之间的联系.
主要方法:
- 文献综述,重点关注时代生物学,新陈代谢和肝脏疾病.
- 对研究睡眠和食计划改变对新陈代谢平衡的影响的分析.
- 综合证据,将昼夜干扰与MASLD和肝细胞癌的发展联系起来.
主要成果:
- 循环节错位显著改变新陈代谢过程和能量平衡.
- 扰乱的昼夜节律促进了有利于肝脏脂肪积累的条件,导致MASLD.
- 有证据表明,昼夜干扰,MASLD和肝细胞癌风险增加之间存在相关性.
结论:
- 循环节障碍是一个重要的环境因素,有助于像MASLD这样的代谢疾病.
- 了解昼夜节律,饮食,睡眠和肝脏健康之间的相互作用对于疾病预防和治疗至关重要.
- 对时间营养和时间治疗的进一步研究可能为管理MASLD和降低癌症风险提供新的策略.
相关概念视频
02:19Circadian Rhythms and Gene Regulation
4.0K
The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent...
4.0K
01:24Overview of Lipid Metabolism
1.0K
Lipid metabolism is a crucial process in the human body that involves the synthesis and degradation of lipids. This process is essential for energy production, cell membrane formation, and hormone production, among other functions.
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
1.0K
01:24Liver Regeneration
3.2K
The liver is an important organ in vertebrates that plays an essential role in metabolism. It is also responsible for storing and redistributing nutrients such as carbohydrates, fats, and vitamins in the body. Additionally, the liver releases bile salts which are critical for digesting food and eliminating toxic metabolites from the body.
Cells of Liver
The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are...
Cells of Liver
The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are...
3.2K
01:30Liver Physiology
417
The liver, an essential organ in the human body, performs over 200 vital functions that can be broadly categorized into metabolic, hematological, endocrine regulation, and bile production.
Metabolic Regulation:
The liver is the central organ involved in regulating blood composition. It stabilizes blood glucose levels, maintaining them within the range of 70–110 mg/dL. When these levels drop, the liver breaks down glycogen reserves and releases glucose into the bloodstream. It can...
Metabolic Regulation:
The liver is the central organ involved in regulating blood composition. It stabilizes blood glucose levels, maintaining them within the range of 70–110 mg/dL. When these levels drop, the liver breaks down glycogen reserves and releases glucose into the bloodstream. It can...
417
01:58Cell Specific Gene Expression
13.4K
Multicellular organisms contain a variety of structurally and functionally distinct cell types, but the DNA in all the cells originated from the same parent cells. The differences in the cells can be attributed to the differential gene expression. Liver cells, whose functions include detoxification of blood, production of bile to metabolize fats, and synthesis of proteins essential for metabolism, must express a specific set of genes to perform their functions. Gene expression also varies with...
13.4K
01:19Overview of Carbohydrate Metabolism
714
Carbohydrate metabolism is a fundamental biochemical process that ensures a constant supply of energy to living cells. The most important carbohydrate is glucose, which can be broken down via glycolysis to enter into the Krebs cycle and eventually lead to the production of ATP through oxidative phosphorylation.
Glucose transport into cells is facilitated by a family of transport proteins called GLUT (Glucose Transporters). GLUT4 is the primary glucose transporter for insulin-stimulated glucose...
Glucose transport into cells is facilitated by a family of transport proteins called GLUT (Glucose Transporters). GLUT4 is the primary glucose transporter for insulin-stimulated glucose...
714