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在通用盐化过程中甲状腺自身免疫 - 可能短期调节,具有长期稳定性.
Navoda Atapattu1, Renuka Jayatissa2, Harendra de Silva1
1Departments of Paediatrics and Paediatric Endocrinology, Lady Ridgeway Hospital, Colombo 08, Sri Lanka.
Nutrients
|January 8, 2025
概括
全球盐化 (USI) 是安全有效的预防缺乏症. 长期研究表明,USI不会增加自身免疫性甲状腺疾病,支持其持续使用.
科学领域:
- 内分泌学 在内分泌学.
- 公共卫生 公共卫生
- 营养 营养 营养 营养 营养
背景情况:
- 全球盐化 (USI) 是预防缺乏症的关键全球战略,成功保护了数百万人.
- 有关USI对心血管健康 (由于盐摄入) 和甲状腺自身免疫的影响存在担忧.
- 全球网络为有效的USI计划提供了指导方针.
研究的目的:
- 评估USI对甲状腺自身免疫标记物的短期影响 (TPOAb,TgAb).
- 评估USI对甲状腺自身免疫和功能的长期安全性和影响.
- 为了解决有关USI计划持续可取性的担忧.
主要方法:
- 对不同人群的横截面研究的分析.
- 检查甲状腺过氧化酶抗体 (TPOAb) 和甲状腺球蛋白抗体 (TgAb) 的水平.
- 评估长期 (长达二十年) 的甲状腺生化功能.
主要成果:
- 短期USI显示甲状腺自身免疫标记物的最小调节与保留甲状腺功能.
- 长期研究表明,TPOAb和TgAb的流行率有所降低.
- 生物化学甲状腺功能保持正常,即使经过二十年的USI.
结论:
- 目前的证据表明,USI是安全的,不会增加自身免疫性甲状腺疾病的患病率.
- 长期化盐似乎是一种安全的公共卫生措施.
- 建议进行进一步的长期,精心设计的研究来证实这些发现.
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