慢性性肠炎的饮食和微生物群调节:证据,挑战和机会
Pierluigi Puca1,2, Angelo Del Gaudio2, Guia Becherucci1
1IBD Unit, UOC CEMAD Centro Malattie dell'Apparato Digerente, Dipartimento di Scienze Mediche e Chirurgiche Addominali ed Endocrino Metaboliche, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, 00168 Rome, Italy.
Nutrients
|January 8, 2025
概括
慢性口袋炎的管理是具有挑战性的,但饮食干预和微生物群调节显示出有前途. 这些策略旨在减少炎症并改善性结肠炎患者的肠道健康,尽管需要更多的研究.
科学领域:
- 胃肠病学 胃肠病学
- 微生物学 微生物学
- 营养科学 营养科学
背景情况:
- 慢性囊会影响大约50%的患者在性结肠炎的恢复性直肠切除术后,这对治疗提出了重大挑战.
- 传统的治疗方法,如抗生素和生物药物,对于症状患者来说通常是不够的.
- 饮食干预和微生物群调制正在成为互补的战略.
研究的目的:
- 审查营养疗法和微生物群调节的最新进展,以管理慢性囊炎.
- 评估益生菌,益生菌和便微生物群移植在缓解囊炎症状方面的有效性.
- 评估饮食干预的临床证据及其对慢性囊炎肠道微生物群的影响.
主要方法:
- 关于营养疗法和微生物群调节的最新文献的叙事综述.
- 对益生菌,益生菌和便微生物群移植研究的分析.
- 评估饮食干预措施 (如低FODMAP,地中海饮食) 的临床证据及其对肠道微生物群的影响.
主要成果:
- 低FODMAP和地中海饮食等饮食方法显示出减少炎症和改善症状的潜力.
- 微生物群调节策略,包括益生菌和便微生物群移植,正在成为安全和有效的.
- 有证据表明,这些干预措施可以恢复微生物多样性并缓解症状,尽管结果有时是矛盾的.
结论:
- 营养和微生物群调节策略为慢性囊炎管理提供了有希望的互补方法.
- 了解这些干预措施对于加强传统疗法和改善患者生活质量至关重要.
- 挑战包括微生物群的变异性,限制性饮食和缺乏标准化的评估方法,需要进一步研究.
相关概念视频
01:21Inflammatory Bowel Disease V: Surgical Management
116
Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
Here are some common surgical interventions for IBD:
Here are some common surgical interventions for IBD:
116
01:30Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
315
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
315
01:17Chronic Bowel Disorders: Introduction
386
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
386
01:50What is Monogastric Digestion?
70.5K
The human body contains a monogastric digestive system. In a monogastric digestive system, the stomach only contains one chamber in which it digests food. Several other animal species also have monogastric digestive systems, including pigs, horses, dogs, and birds. This chapter, however, focuses on the human digestive system.
70.5K
01:29Chronic Pancreatitis II: Collaborative Care
70
The management of chronic pancreatitis is multifaceted, involving a comprehensive approach that includes thorough assessment, diagnostic testing, and a variety of management strategies.
Assessment:
Assessment:
70
01:29Inflammatory Bowel Disease IV: Pharmacological Management
110
Upon diagnosis, managing Inflammatory Bowel Disease (IBD) involves addressing several crucial aspects. The primary goals include resting the bowel, correcting malnutrition, and providing symptomatic relief. Resting the bowel may consist of medications to reduce inflammation and promote healing. Correcting malnutrition is essential, often requiring dietary adjustments and nutritional supplements. Symptomatic relief aims to ease pain, diarrhea, and other discomforts in IBD.
Pharmacologic...
Pharmacologic...
110