母亲肠道微生物组介导的认知发育和障碍的表观遗传修饰:治疗创新的新前沿
Shabnam Nohesara1, Hamid Mostafavi Abdolmaleky1,2, Faith Dickerson3
1Department of Medicine (Biomedical Genetics), Boston University Chobanian and Avedisian School of Medicine, Boston, MA 02218, USA.
Nutrients
|January 8, 2025
概括
肠道微生物组通过表观遗传机制影响认知功能和心理健康. 准肠道微生物群可能为所有生命阶段的认知障碍提供新的治疗策略.
科学领域:
- 神经科学是一个神经科学.
- 微生物学 微生物学
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
背景情况:
- 认知障碍是精神疾病的一个重要问题,遗传和表观遗传因素发挥着作用.
- 肠道微生物组受到环境因素的影响,影响大脑表观遗传学,行为和认知.
- 新兴研究表明,肠道微生物群具有改善认知缺陷的潜力.
研究的目的:
- 审查认知障碍,肠道微生物组变化和表观遗传变化之间的相互作用.
- 检查影响肠道微生物群的非遗传因素及其对认知表现的影响.
- 探索基于微生物组的干预措施对认知健康的潜力.
主要方法:
- 关于认知障碍,肠道微生物群和表观遗传学研究的文献综述.
- 分析生活方式,饮食和年龄等因素对微生物组的组成和功能的影响.
- 预测生物标志物和治疗策略的探索.
主要成果:
- 肠道微生物组的改变通过表观遗传途径与认知障碍有关.
- 诸如母亲的饮食和生活方式等因素显著影响肠道微生物群的表观遗传影响.
- 孕产妇的肠道微生物组特征和表观遗传生物标志物可以预测认知能力下降的风险.
结论:
- 肠道微生物组是认知功能和发展的关键因素.
- 具有表观遗传效应的肠道微生物向疗法在预防/治疗认知障碍方面表现有前途.
- 需要进一步的研究,以克服将这些疗法转化为临床实践的挑战.
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