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药理学和转录学综合性分析预测,通过准CCL2和Esr1,复星将改善微塑料诱导的肺损伤

Yadong Zhang¹, Jingyi Ren¹, Siqi Zhu¹

¹Hebei Key Laboratory of Environment and Human Health, Department of Nutrition and Food Hygiene, School of Public Health, Hebei Medical University, Shijiazhuang 050017, China.

|January 8, 2025

概括

Resveratrol (RES) 通过向Esr1和Ccl2.2,可以保护肺部免受微塑料 (MP) 的损害. 这项研究为预防和治疗MP引起的肺损伤提供了新的见解.

科学领域:

环境健康环境健康
毒理学毒理学毒理学
分子生物学分子生物学

背景情况:

微塑料 (MP) 是广泛存在的环境污染物,具有潜在的人类健康风险.
肺部是微塑料暴露的主要地点.
饮食中的多醇Resveratrol (RES) 已知具有抗氧化和抗炎性质,但其对微塑性塑料引起的肺损伤的保护作用尚未被探索.

研究的目的:

为了研究Resveratrol (RES) 对微塑料 (MP) 诱导的肺损伤的潜在保护作用.
确定RES涉及减轻MP诱导的肺损伤的分子标.

主要方法:

生物信息分析用于识别对MPs的反应中差异表达的基因 (DEGs).
数据库检索和分析以确定可再生能源目标.
拓分析和机器学习用于选核心目标.
分子对接和分子动力学 (MD) 模拟以验证 RES-目标相互作用.

主要成果:

确定了1235个DEG,其中66个重叠与739个已确定的可再生能源目标.
确定了Esr1和Ccl2作为可再生能源的潜在核心目标.
分子对接和MD模拟证实了RES和Esr1/Ccl2.2之间的结合亲和力.

结论:

Resveratrol (RES) 通过向Esr1和Ccl2.2,可以缓解微塑料 (MP) 引起的肺损伤.
这项研究为MP引起的肺损伤的预防和治疗提供了新的治疗视角.

关键词:

肺部受伤的原因是肺部受伤.微塑料微塑料的使用网络药理学网络药理学复星醇是一种复星醇.翻译学翻译学翻译学翻译学

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