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基于沉聚合物的分子打印聚合物:一种用于通过皮肤输送黄素的新方法
Muhammad Cholid Djunaidi1, Viona Resda Putri1, Nesti Dwi Maharani1
1Department of Chemistry, Faculty of Science and Mathematics, Diponegoro University, Jl. Prof. Soedharto SH, Tembalang, Semarang 50275, Indonesia.
Polymers
|January 8, 2025
概括
这项研究开发了一种分子印记聚合物 (MIP) 用于控制的通过皮肤递送黄素. MIP表现出黄素吸附的增强和释放率的降低,使其成为药物输送应用的有希望的候选者.
科学领域:
- 聚合物化学 聚合物化学
- 材料科学 材料科学 材料科学
- 制药科学 制药科学
背景情况:
- 黄素是一种天然化合物,具有治疗潜力,但面临生物可用性挑战.
- 通过皮肤递送药物提供了一种非侵入性的全身药物管理途径.
- 开发合适的载体对于黄素等疏水性药物的有效透皮输送至关重要.
研究的目的:
- 为了合成和表征分子印记聚合物 (MIP) 用于黄素通过皮肤输送.
- 为了评估黄素的MIP的吸附能力和释放动力学.
- 评估MIP作为通过皮肤释放黄素的受控释放系统的潜力.
主要方法:
- 使用甲基烯酸和乙烯基甘醇二甲基烯酸盐的沉聚合.
- 使用SEM-EDX和FTIR光谱学进行形态和化学表征.
- 根据兰格穆尔异热法进行吸附研究,根据希古奇模型进行释放动力学研究.
主要成果:
- 合成的MIP表现出一个统一的颗粒形态.
- 与非印制聚合物 (NIP,3.219 mg/g) 相比,MIP显示了更高的吸附能力 (4.239 mg/g),印制效率为1.317.
- 与NIP (51.50%) 相比,MIP显示黄素释放率降低 (8小时后41.26%),表明控制的扩散.
结论:
- 开发的MIP适合黄素通过皮肤输送.
- 打印过程有效地修改了聚合物矩阵,以控制药物释放.
- MIP显示出作为黄素通过皮肤传递受控的载体的潜力.
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