使用基托多电解质复合物与酸盐和酸盐/基烯基甲基纤维素甲酸盐量身定制梅萨拉纳米悬浮
Amélia Aparecida Rocca Pereira1, José Vitor Melchiades Aparecida1, Maria Eduarda Ramalho1
1Faculty of Pharmaceutical Science, UNESP-São Paulo State University, Rodovia Araraquara-Jaú, Km 01, Araraquara 14801-902, Brazil.
Pharmaceutics
|January 8, 2025
概括
这项研究表明,调整梅萨拉纳米悬浮中桑与酸盐和基基甲基纤维素酸盐的比率可以控制颗粒大小和电荷. 这允许创建具有特定,定制特性的药物颗粒.
科学领域:
- 材料科学 材料科学 材料科学
- 制药科学 制药科学
- 合体化学 合体化学
背景情况:
- 梅萨拉 (MSZ) 纳米悬浮对于有针对性的药物输送至关重要.
- 控制纳米悬浮的合性质是优化药物疗效的关键.
- 酸盐 (CS),酸盐 (ALG) 和基基甲基纤维素酸盐 (HP) 是用于修改纳米悬浮特性的聚合物.
研究的目的:
- 为了研究不同基托比例对梅萨拉纳米悬浮的体性质的影响.
- 探索使用奇多-酸盐和奇多-酸盐-基-甲基纤维素酸盐复合物来定制纳米悬浮特性.
- 开发一种生产具有特定可控制性质的mesalazine纳米颗粒的方法.
主要方法:
- 纳米悬浮是使用自下而上的酸反应方法制备的.
- 梅萨拉纳米悬浮被修改为二进制 (CS/ALG) 和三进制 (CS/ALG/HP) 聚电解质复合物.
- 分析了粒子大小,多分散性指数 (PDI),泽塔潜力,形态学和药物协会效率.
主要成果:
- 基托桑比例的增加导致了更小的颗粒大小和更低的多分散率指数.
- 泽塔潜力受到相对酸盐比例的显著影响,并观察到逆转.
- 经过优化的二元CS/ALG纳米悬浮,在pH值4.0-6.0.0之间显示出大约310-325nm的粒子大小和正泽塔电位 (+40.8至+43.6mV).
- 优化的三元CS/ALG/HP纳米悬浮在pH值4.0-6.0时表现出大约317-364nm的粒子大小和正泽塔电位 (+33.9mV).
结论:
- 基托桑基聚电解质复合物与酸盐和HP有效调节梅萨拉纳米悬浮的特性.
- 这种方法使得制造具有量身定制的合性特征的纳米悬浮成为可能.
- 这些发现支持为制药应用开发定制的梅萨拉纳米颗粒.
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