同型化,溶解和稳定性冷药物-药物同型超和输送系统与RT-不稳定的无形组件
Yan-Fei Zhang1, Qian Yao2, Xiao-Ying Lin1
1School of Pharmacy, Jilin Medical University, Jilin 132013, China.
Pharmaceutics
|January 8, 2025
概括
含有室温不稳定的药物的药物-药物共变体系统 (ddCAM) 通过火冷却成功形成. 这些系统增强了药物的溶解性,溶解性和稳定性,提供了新的配方可能性.
科学领域:
- 制药科学 制药科学
- 药物输送系统 药物输送系统
- 材料科学 材料科学 材料科学
背景情况:
- 超和药物递送系统 (SDDS) 对于提高生物制药分类系统 (BCS) II类药物的溶解性和生物吸收性至关重要.
- 同形 (CAM) 系统,特别是药物-药物CAM (ddCAM),为组合治疗提供了基于聚合物的无形SDDS (aSDDS) 的替代方案.
- 无形药物在室温 (RT) 的稳定性对形成和维护ddCAMs提出了挑战,对RT不稳定的组件的研究有限.
研究的目的:
- 为了研究通过冷却冷却形成的含有RT不稳定的组件的ddCAMs的共同形态化,溶解,溶解性和稳定性.
- 为了探索"FEL-NAP"和"NTP-NAP"ddCAM对的形成,使用纳素 (NAP) 作为RT不稳定的组件.
主要方法:
- 使用冷却冷却方法制备"FEL-NAP"和"NTP-NAP"的药物-药物共成形系统.
- 对准备的ddCAMs的共同形态化,溶解,溶解度和物理稳定性概况进行了全面的分析.
- 利用各种分析技术来描述含有RT不稳定的纳普罗的ddCAM.
主要成果:
- 与RT不稳定的组件的ddCAMs的同变形和稳定性取决于使用冷却冷却时的药物配对和比率.
- 火冷却和同形系统形成都改善了单个活性药物成分 (API) 的溶解,溶解性和物理稳定性.
- 成功形成FEL-NAP和NTP-NAP的ddCAM证明了将RT不稳定的药物纳入药物的可行性.
结论:
- 这项研究提供了关于FEL-NAP和NTP-NAP ddCAMs的共同形态化,溶解和稳定性的见解.
- 这些发现有助于开发含有室温不稳定的药物的新型ddCAM配方.
- 杀冷却是一种有效的方法,可以创建具有改进药物特性的稳定ddCAM.
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