喷雾干燥组合利沃弗洛克萨辛-安布罗克索尔干粉吸入器配方的开发和表征
Ruwani K Suraweera1,2, Kirsten M Spann2, Emad L Izake3
1Pharmacy Discipline, School of Clinical Sciences, Faculty of Health, Queensland University of Technology, Brisbane, QLD 4000, Australia.
Pharmaceutics
|January 8, 2025
概括
这项研究开发了喷雾干燥的微粒,结合了勒沃素和安布罗克索尔,用于下呼吸道感染. 最佳的1:1比率与白增强的肺部输送,显示治疗LRTIs的潜力.
科学领域:
- 制药科学 制药科学
- 药物输送系统 药物输送系统
- 呼吸系统医学 呼吸系统医学
背景情况:
- 开发用于下呼吸道感染 (LRTI) 的新药输送系统.
- 复合微粒的探索,结合了levofloxacin (抗生素) 和ambroxol (具有抗菌性质的粘合剂).
研究的目的:
- 开发和描述喷雾干燥的复合微粒的莱沃素和安布罗克索尔LRTIs.
- 为了优化药物比率,并评估白素作为扩散性增强剂的影响.
主要方法:
- 在不同质量比 (1:1, 1:0.5, 1:0.25) 的levofloxacin-ambroxol复合微粒的喷雾干燥,有或没有leucine.
- 使用ATR-FTIR,SEM,PXRD和TGA进行表征.
- 在试验室中使用双阶段冲击器和RP-HPLC进行药物定量化进行气溶液化性能评估.
主要成果:
- 获得了球形微粒 (1.9-2.9微米),适合深层肺沉积.
- 氨酸显著改善了产量,流动性质和气溶化.
- 在1: 1的levofloxacin与ambroxol比率显示出最佳的流量和细颗粒分数 (FPFs).
- 添加5%的白显著增强了FPF,可能是通过增加表面水性.
结论:
- 喷雾干燥的乐沃素和安布罗的复合微粒显示出有效的肺部输送的巨大潜力.
- 优化的配方与白是有希望的管理LRTIs.
- 均衡的药物比率对于实现所需的颗粒特性和气溶性能至关重要.
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