新型脂质配方增加了口服大麻素 (CBD) 的吸收
Edward Chesney1,2,3, Ndabezinhle Mazibuko4,5, Dominic Oliver6,7
1Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London SE5 8AB, UK.
Pharmaceutics
|January 8, 2025
概括
一种新的脂质配方显著增强了大麻 (CBD) 的口服吸收,改善了其用于治疗中枢神经系统疾病的生物可用性. 这种配方还减少了肠道细菌对CBD吸收的影响.
科学领域:
- 药理学 药理学是指药理学的学科.
- 药物运输 药物运输 药物运输
- 神经科学是一个神经科学.
背景情况:
- 大麻 (CBD) 是一种已批准的治疗方法,也是中枢神经系统疾病的潜在治疗方法.
- 由于CBD的口服,其生物可用性较差.
- 需要新的配方来提高CBD的治疗疗效.
研究的目的:
- 评估一种新型脂质配方对大麻 (CBD) 的口服吸收和组织分布的影响.
- 为了比较CBD在人体脂质与粉末配方中的药理动力学.
- 为了评估CBD在小鼠中的组织分布,使用脂质配方与水溶液对比.
主要方法:
- 一项对健康志愿者的双盲交叉研究比较了脂质和粉末配方中单次1000毫克的CBD剂量.
- 分析了包括AUC0-48在内的药理动力学参数.
- 在用MALDI-MS成像检查小鼠中检查CBD的组织分布,在用脂质或水性配方进行口腔 gavage后.
主要成果:
- 与粉末配方相比,脂质配方导致CBD的血暴露 (AUC0-48) 增加了9倍.
- 从粉末配方中吸收的CBD与肠道细菌和胆酸度相关,这种效应被脂质配方减弱.
- 在小鼠中,脂质配方导致所有器官中可测量的CBD度,而水性配方则没有.
结论:
- 在脂质配方中口服CBD显著提高了胃肠道吸收和生物可用性.
- 脂质配方减轻了肠道微生物群对CBD吸收的影响.
- 改善的吸收和分布表明,在中枢神经系统疾病中,治疗结果可能会得到改善.
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