揭示了Cmaxf2因子的潜力,应用于试点生物可用性/生物等价性研究 - - 一个用帕佐帕尼布制药的案例研究

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Updated: Jun 3, 2025

Optimized LC-MS/MS Method for the High-throughput Analysis of Clinical Samples of Ivacaftor, Its Major Metabolites, and Lumacaftor in Biological Fluids of Cystic Fibrosis Patients
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Optimized LC-MS/MS Method for the High-throughput Analysis of Clinical Samples of Ivacaftor, Its Major Metabolites, and Lumacaftor in Biological Fluids of Cystic Fibrosis Patients

Published on: October 15, 2017

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Sara Carolina Henriques1,2, Ana Leblanc1, Sérgio Simões3,4

  • 1BlueClinical Ltd., Senhora da Hora, 4460-439 Matosinhos, Portugal.

Pharmaceutics
|January 8, 2025
PubMed
概括

在试点研究中,f2因子为评估生物等价性的传统方法提供了一个有希望的替代方案. 这种方法有助于减少不确定性,并指导进行更大规模的关键试验的决策,即使具有高可变性.

关键词:
生物等价性 生物等价性这就是F2因子.仿制药是指一般的药物.药物是高度变化的药物.这就是巴索巴尼比和平.药物动力学 药物动力学试点研究试点研究

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