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通过微尺度的大脑机器接口光学控制的药物输送,使用集成的上转换纳米粒子.

Levente Víg1, Anita Zátonyi1, Bence Csernyus1

  • 1Research Group for Implantable Microsystems, Faculty of Information Technology & Bionics, Pázmány Péter Catholic University, H-1083 Budapest, Hungary.

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概括

研究人员将上转化纳米粒子 (UCNPs) 与大脑机器接口集成,以实现精确的,光激活的药物输送. 这种新的方法使同时的神经记录和植入物附近局部物质释放成为可能.

关键词:
生物医学植入物植入物大脑机器接口 机器接口药物输送是药物输送的过程.电前皮质谱 (ECC) 是一种电前皮质谱.通过将纳米颗粒转化为上方的纳米粒子.

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科学领域:

  • 生物医学工程 生物医学工程
  • 纳米技术 纳米技术
  • 神经科学是一个神经科学.

背景情况:

  • 微工程生物医学植入物需要先进的药物输送系统.
  • 上转化纳米粒子 (UCNPs) 为控制释放应用提供独特的光学性能.

研究的目的:

  • 在微电皮质谱 (ECoG) 植入物上集成化核心的UCNP.
  • 开发一个空间控制,可光学释放的药物输送系统.
  • 评估UCNP修改ECoG的可行性,用于同时进行神经记录和药物释放.

主要方法:

  • 对UCNP的表面修改和对基于的ECoG植入物进行固定.
  • 利用近红外可刺激,可见发射UCNP进行光化学反应.
  • 描述UCNP的整合,稳定性 (体外/体内),以及对电生理功能的影响.

主要成果:

  • 成功地将UCNP集成到ECoG植入物中.
  • 通过光化学反应证明光诱导的局部染料释放.
  • 评估UCNP稳定性和对电生理学记录能力的最小影响.

结论:

  • 经UCNP修改的ECoG植入物可以作为综合药物输送装置.
  • 这项技术可以通过光学激活触发局部物质释放.
  • 具有同时进行神经监测和在脑组织中向治疗的潜力.