艾滋病毒感染者的COVID-19疫苗接种和CD4/CD8细胞计数的暂时增加:来自中国的证据
Yanyan Li1,2, Yingying Lin3, Yunyun Yi4
1Center of Integrative Medicine, Beijing Ditan Hospital, Capital Medical University, Beijing 100015, China.
Vaccines
|January 8, 2025
概括
艾滋病毒感染者 (PWH) 接种COVID-19疫苗显示CD4计数和CD4/CD8比率暂时增加. 这种增强免疫反应与对HIV病毒载荷的不良影响无关.
科学领域:
- 免疫学 免疫学 免疫学
- 病毒学 病毒学
- 疫苗学 疫苗学 疫苗学
背景情况:
- COVID-19 疫苗对SARS-CoV-2 有效.
- COVID-19疫苗接种对艾滋病毒感染者 (PWH) 免疫病毒学标志物的影响尚不清楚.
研究的目的:
- 评估COVID-19疫苗接种对PWH.免疫病毒学参数的影响.
- 评估疫苗接种后的CD4计数,CD4/CD8比率和HIV病毒载量的变化.
主要方法:
- 包括372个PWH; 接种疫苗和未接种疫苗的群体使用倾向分数进行匹配.
- 分析了群体之间的免疫病毒学标记的差异.
- 使用威尔科克森签名排名测试,检测疫苗接种期间CD4,CD8和HIV病毒载量的变化.
主要成果:
- 与未接种疫苗的PWH相比,接种疫苗的PWH在第三剂后两个月内显示出较高的CD4/CD8比率.
- 在第二次和第三次剂量后,观察到CD4计数和CD4/CD8比率的短暂增加.
- 接种COVID-19疫苗并没有对艾滋病毒病毒载量产生负面影响.
结论:
- 接种COVID-19疫苗会导致PWH中CD4计数和CD4/CD8比率的暂时增加.
- 增强的免疫反应可能会随着时间的推移而减弱.
- 接种疫苗对PWH的HIV病毒载量没有不利的风险.
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