后COVID-19疫苗接种和长期COVID:来自患者报告数据的见解
Tom C Quach1, Mitchell G Miglis2, Lu Tian3
1Stanford University School of Medicine, Stanford, CA 94305, USA.
Vaccines
|January 8, 2025
概括
大多数患有SARS-CoV-2 (PASC) 后急性后续症状的人在接种COVID-19疫苗后没有显著的症状变化. 需要进一步的研究来了解疫苗.
科学领域:
- 免疫学 免疫学 免疫学
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 众所周知,COVID-19疫苗可以降低急性感染的严重程度,并可能降低患长期COVID或SARS-CoV-2 (PASC) 后急性后续症的风险.
- 关于在PASC开始后接种的COVID-19疫苗对持续症状和疾病轨迹的影响的数据有限.
研究的目的:
- 为了调查COVID-19疫苗接种后和PASC症状之间的关联.
- 分析SARS-CoV-2疫苗接种对两组独立患者PASC症状变化的影响.
主要方法:
- 在斯坦福 PASC 诊所 (2021 年 5 月至 2022 年 5 月) 的 128 名 PASC 患者的自我报告数据的回顾性图表审查.
- 一个2023年的跨国调查评估了484个人的PASC症状.
- 对人口特征,BMI和与PASC症状变化相关的疫苗接种史的分析.
主要成果:
- 在PASC诊所队列中,60.2%的患者报告没有症状变化,17.2%的患者在接种疫苗后症状改善,22.7%的患者在接种疫苗后症状恶化.
- 在调查队列中,60.5%的人报告没有症状变化,19.2%的症状改善,20.2%的症状在接种疫苗后恶化.
- 人口统计学与症状变化没有显著关联;BMI与一个队列的改善有关,而另一个队列则是强化史.
结论:
- 大多数PASC患者在接受COVID-19疫苗接种后没有经历任何显著的整体症状变化.
- 进一步的研究对于阐明COVID-19疫苗接种和PASC之间的复杂关系至关重要.
关键词:
COVID-19 免疫接种方法接种COVID-19疫苗的时间这是COVID-19疫苗.接种SARS-CoV-2疫苗的方法长时间的COVID.这是后急性COVID-19综合征.在SARS-CoV-2感染的急性后续症状.更多相关视频
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