CD46 是人类腺病毒 64 型的蛋白质受体
Eugene Y Wu1, Alexander M Robertson1, Hanglin Henry Zhu1
1Department of Biology, University of Richmond, Richmond, VA 23173, USA.
Viruses
|January 8, 2025
概括
人类腺病毒D64 (HAdV-D64) 使用CD46和酸作为细胞进入的受体,类似于HAdV-D37. 阻止这种相互作用可以防止与HAdV-D64相关的眼部感染.
科学领域:
- 病毒学 病毒学
- 眼科医生 眼科 眼科
- 细胞生物学 细胞生物学
背景情况:
- 一些人类腺病毒D种 (HAdV-D19,D37,D64) 引起流行性角膜结膜炎.
- HAdV-D37利用CD46 (膜辅因子蛋白) 和酸作为细胞受体.
- HAdV-D64与HAdV-D37具有遗传相似性,但由于重组,它在关键囊蛋白中有所不同.
研究的目的:
- 为了研究HAdV-D64用于病毒进入的细胞受体.
- 要确定CD46和酸是否作为HAdV-D64.4的受体起作用.
- 探索HAdV-D64在基因传递和眼部疾病治疗干预方面的潜力.
主要方法:
- 具有约束力的测试来评估HAdV-D64与CD46和酸的相互作用.
- 使用CD46表达细胞和CD46阴性细胞进行细胞培养实验.
- 抑制研究阻止了HAdV-D64与CD46.6的结合.
- 对人类结膜上皮细胞上CD46表达的分析.
主要成果:
- HAdV-D64病毒直接与CD46结合,作为一个受体.
- CD46和酸在各种细胞类型上充当HAdV-D64的粘附受体.
- CD46的表达赋予了对CD46阴性细胞中HAdV-D64进入的敏感性.
- 阻止HAdV-D64-CD46相互作用显著抑制病毒的进入和基因传递.
- CD46在人类结膜上皮细胞上表达,并与HAdV-D64.4结合.
结论:
- HAdV-D64利用CD46和酸作为细胞进入的关键受体.
- 结膜细胞上的CD46表达表明在HAdV-D64眼部感染中发挥了作用.
- 准HAdV-D64-CD46相互作用为预防或治疗腺病毒相关的眼部疾病提供了潜在的策略.
- HAdV-D64具有向结膜细胞提供向基因的潜力.
关键词:
CD46 CD46 CD46 CD46 CD46 CD46 CD46 CD46 CD46 CD46 CD46 CD46 CD46 CD46 CD46 CD46 CD46腺病毒的病毒.流行性角质结膜炎的流行病.膜辅助因子蛋白质是一种膜辅助因子蛋白质.接收器 接收器 接收器接收器更多相关视频
13:36Utilizing the Antigen Capsid-Incorporation Strategy for the Development of Adenovirus Serotype 5-Vectored Vaccine Approaches
Published on: May 6, 2015
10.4K
08:14Combined Genetic and Chemical Capsid Modifications of Adenovirus-Based Gene Transfer Vectors for Shielding and Targeting
Published on: October 26, 2018
8.3K
相关概念视频
02:30Metastasis
5.4K
Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
5.4K
01:26Antigens Involved in Adaptive Immunity
1.7K
An antigen is any substance the immune system identifies as foreign and potentially harmful to the body, prompting an immune response. Antigens have two functional properties: immunogenicity and reactivity. Immunogenicity is the ability of an antigen to stimulate a specific immune response. At the same time, reactivity describes the antigen's ability to react with the cells and antibodies produced in response to it.
Complete Antigens
Complete antigens possess both immunogenicity and...
Complete Antigens
Complete antigens possess both immunogenicity and...
1.7K
01:28Diversity of Antigen Receptors
2.1K
Antigen receptors are essential components of the immune system crucial in defending the body against foreign invaders. These receptors are present on the surface of B and T cells, enabling them to recognize antigens and mount an appropriate immune response.
Before encountering any antigen, lymphocytes express these receptors. On B cells, the antigen receptor is a membrane-bound antibody molecule called BCR; on T cells, it is a T cell receptor or TCR. B and T cell receptors are composed of two...
Before encountering any antigen, lymphocytes express these receptors. On B cells, the antigen receptor is a membrane-bound antibody molecule called BCR; on T cells, it is a T cell receptor or TCR. B and T cell receptors are composed of two...
2.1K