在肯尼亚中部高地的人类和牲畜之间,有神秘的裂谷热病病毒传播的血清学证据
Silvia Situma1,2,3, Evans Omondi4,5, Luke Nyakarahuka6,7
1Department of Medical Microbiology and Immunology, University of Nairobi, Nairobi 00202, Kenya.
Viruses
|January 8, 2025
概括
裂谷热 (RVF) 病毒正在蔓延到肯尼亚高原的新地区,最近在牲畜和人类中发现了暴露. 这表明,在以前不受影响的地区,未来RVF流行病的风险越来越大.
科学领域:
- 兽医医学 兽医医学 兽医医学
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 裂谷热 (RVF) 通常发生在裂谷热病热点,但最近在东非高地报告了小群体.
- 导致RVF病毒在这些高原地区在流行期间循环传播的生态因素尚不清楚.
研究的目的:
- 调查RVF病毒在肯尼亚中部高地动物和人类之间循环传播的发生情况.
- 确定与人类和牲畜的RVF暴露相关的社会人口和环境风险因素.
主要方法:
- 肯尼亚Murang'a县的发烧患者 (n=1468) 的2年前性医院研究,随后进行了人体 (n=282) 和牲畜 (n=706) 的横截面调查.
- 来自患者和动物的血清被测试为RVF病毒RNA和抗RVFVIgG抗体. 使用多变量逻辑回归来分析风险因素.
主要成果:
- 在人类或牲畜中没有检测到RVF病毒RNA. 然而,4.4%的牲畜和2.0%的人的抗RVFVIgG检测结果呈阳性,表明最近的暴露.
- 人类暴露于RVF的风险因素包括男性性别,生牛奶消费和靠近采石场的风险因素. 牛比绵羊和山羊更有可能呈病毒阳性.
结论:
- 这些发现表明,最近在肯尼亚中部高地暴露于RVF病毒,这表明病毒的地理分布正在扩大.
- 这种扩大分布构成未来更广泛的RVF流行病的更大风险,需要加强监测和控制措施.
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