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在SARS-CoV-2感染两年后,长期COVID症状的持续性:一个潜在的纵向队列研究
Gili Joseph1,2, Ili Margalit1,2,3, Yael Weiss-Ottolenghi1
1The Sheba Pandemic Preparedness Research Institute (SPRI), Sheba Medical Center, Tel Hashomer, Ramat Gan 52621, Israel.
Viruses
|January 8, 2025
概括
持续的长期COVID症状在感染后两年很常见,影响了21.5%的个人. 女性性别,吸烟和急性感染严重程度增加了风险. 血液生物标志物与持续症状无关.
科学领域:
- 传染性疾病 传染性疾病
- 免疫学 免疫学 免疫学
- 神经学 神经学
背景情况:
- 全球数百万人经历了SARS-CoV-2感染后的持续症状,称为长期COVID.
- 这项研究的重点是:
- 持续的 长期COVID,
- 被定义为持续至少两年的症状.
- 调查多系统症状,包括疲劳,疼痛,认知问题和感官变化.
研究的目的:
- 评估持续的长期COVID症状的患病率和特征.
- 确定与持续长期COVID相关的临床因素和血液生物标志物.
- 了解在轻度SARS-CoV-2Delta变种感染后接种疫苗的成年人中的风险因素.
主要方法:
- 对1258名接种疫苗的成年人进行了调查,他们先前患有轻微的SARS-CoV-2Delta变种感染.
- 在感染后两年通过问卷评估持续的长期COVID症状.
- 用于流行率估计和临床特征和生物标志物相关联的逻辑回归的权重调整.
主要成果:
- 23%的受访者报告了持续的长期COVID症状;加权流行率为21.5%.
- 女性性别,吸烟和更高的急性感染严重程度与持久症状有关.
- 评估的血液生物标志物和持续的长期COVID之间没有发现显著的关联.
结论:
- 持续的长期COVID在接种疫苗的成年人中在轻微的SARS-CoV-2三角体感染后两年非常普遍.
- 特定的子组,包括女性和吸烟者,面临更高的风险.
- 进一步的研究对于理解生物机制和开发治疗方法至关重要.
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