长方形重复性横磁性单相与双相刺激用于主要抑郁障碍:一个随机控制的试验试验
Michelle S Goodman1, Daniel M Blumberger2, Mehran Talebinejad3
1Temerty Centre for Therapeutic Brain Intervention, Centre for Addiction and Mental Health, Toronto, Ontario, Canada.
概括
双相和单相矩形重复性跨磁刺激 (rTMS) 都是治疗抑郁症的安全和有效方法. 这项试点研究发现,对于治疗耐药性抑郁症 (TRD) 的两种rTMS脉冲形状之间的结果没有显著差异.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 医疗技术 医疗技术 医学技术
背景情况:
- 重复性横磁性刺激 (rTMS) 是FDA批准的治疗耐治疗抑郁症 (TRD) 的非侵入性治疗方法.
- 技术的局限性阻碍了优化RTMS脉冲形状的研究.
- 这项研究研究了新的双相和单相矩形rTMS协议.
研究的目的:
- 在TRD患者中评估双相和单相矩形rTMS的可行性和耐受性.
- 评估这些新型RTMS脉冲形状对TRD的初步疗效.
- 为了比较双相与单相矩形rTMS的结果.
主要方法:
- 一项试点研究涉及20名被诊断患有TRD的成年参与者.
- 随机管理双相和单相矩形rTMS超过六周 (30次会议,3000脉冲/会议).
- 神经心理测试在治疗前,治疗后以及1,4周和12周的随访后进行.
主要成果:
- 18名参与者完成了这项研究;两个人退出了.
- 双相和单相矩形rTMS都显著减少了TRD患者的抑郁症状.
- 两组之间没有观察到关于抑郁症得分变化,反应率或缓解率的显著差异.
结论:
- 双相和单相矩形rTMS是TRD的安全和耐受良好的治疗方法.
- 需要进一步的大规模,双盲,假控制试验来证实这些发现.
- 这项研究为新型rTMS脉冲形状的有效性提供了初步证据.
相关概念视频
02:07Blind Procedures
Ideally, the people who observe and record the children’s behavior are unaware of who was assigned to the experimental or control group, in order to control for experimenter bias. Experimenter bias refers to the possibility that a researcher’s expectations might skew the results of the study. Remember, conducting an experiment requires a lot of planning, and the people involved in the research project have a vested interest in supporting their hypotheses. If the observers knew which child was...
01:11Blinding
Blinding is a commonly used method of not telling participants which treatment a subject is receiving. Blinding is a critical part of a randomized control trial or RCT. It reduces the bias that affects the results. In an RCT, blinding is used in the form of a placebo. A placebo effect occurs when untreated subjects falsely believe they have received the treatment and report improved symptoms. A placebo or a dummy treatment is administered to subjects to negate the bias caused by such an effect.