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长寿男性的甲基组分析破译了与人类男性寿命相关的DNA甲基化修饰

Fu-Hui Xiao¹, Hao-Tian Wang², Long Zhao³

¹Key Laboratory of Genetic Evolution & Animal Models (Chinese Academy of Sciences), Key Laboratory of Healthy Aging Research of Yunnan Province, Kunming Key Laboratory of Healthy Aging Study, KIZ/CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650201, China; Department of Pharmacology, School of Medicine, Ningbo University, Ningbo, Zhejiang 315211, China.

|January 8, 2025

概括

长寿男性表现出明显的DNA甲基化模式,这可能有助于他们的健康衰老,尽管表观遗传衰老速度更快. 这些模式可以作为男性长寿潜力的生物标志物.

科学领域:

表观遗传学在表观遗传学中,表观遗传学是指表观遗传学.
基因组学就是基因组学.
长寿研究研究长寿研究

背景情况:

男性在长寿期间的健康状况比女性更好,这是一个悖论,不能完全由DNA甲基化解释.
了解男性健康衰老的表观遗传基础对于开发有针对性的干预措施至关重要.

研究的目的:

调查长寿男性 (LLM) 的DNA甲基化概况,以确定与健康长寿相关的独特表观遗传特征.
探索这些甲基化模式作为预测男性寿命的生物标志物的潜力.

主要方法:

全基因组双硫酸盐测序对四组进行:LLMs,长寿女性 (LLWs),年轻男性 (YMs) 和年轻女性 (YWs).
差异甲基化基因组单位 (DMU) 被确定并分析了它们与长寿和与健康相关基因的关系.
使用弹性网分类器验证已识别的DMU作为潜在的生物标志物.

主要成果:

与LLW相比,LLM显示了一个加速的甲基化衰老率.
数以千计的DMU在LLM中被确定,独立于时间和性别,作为长寿的潜在甲基化标志物.
许多已确定的DMU位于与健康相关的基因附近,包括PIWIL1和EXT1,这表明它在调节基因转录以抑制与年龄相关的疾病方面发挥了作用.

结论:

显著的DNA甲基化模式是长寿男性的特征,有助于他们的健康衰老和长寿.
这些特定于LLM的甲基化特征可能通过基因调节在缓解与年龄相关的疾病方面发挥作用.
已确定的DMU作为表观遗传生物标志物,有望用于评估男性的长寿潜力.

关键词:

科普:分子生物学分子生物学通过DNA甲基化.表观遗传学是指表观遗传学.长寿的人是长寿的男人.长寿长寿是一个问题.性别差异的性别差异.

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