芝麻素通过恢复肠道微生物群组成和肠道屏障功能来缓解过敏引起的腹
Yu Li1, Fan Wu2, Yongli Wang1
1College of Food Science and Engineering, Key Laboratory of Food Nutrition and Human Health in Universities of Shandong, Shandong Agricultural University, Taian 271018, China.
Journal of agricultural and food chemistry
|January 8, 2025
概括
从芝麻种子中提取的芝麻胺可以治疗过敏性腹. 它通过平衡微生物群,增加有益的脂肪酸和加强肠道屏障来改善肠道健康.
科学领域:
- 免疫学 免疫学 免疫学
- 胃肠病学 胃肠病学
- 微生物组研究的研究.
背景情况:
- 食物过敏原引发过敏性腹,损害大肠和削弱肠道屏障.
- 芝麻素 (sesamin) 是一种芝麻质,具有免疫调节的潜力,但其对肠道健康的影响尚不清楚.
研究的目的:
- 在小鼠模型中研究芝胺对卵胺诱导的过敏腹的治疗作用.
- 探索芝胺对肠道屏障功能,免疫反应和肠道微生物群的影响.
主要方法:
- 建立了一个卵胺诱导的过敏腹小鼠模型.
- 分析了胺治疗对肠道完整性,免疫细胞活性,细胞因子水平,肠道微生物群和代谢物产生的影响.
主要成果:
- 在过敏性腹模型中,胺治疗减轻了肠道损伤和改善了屏障功能.
- 胺调节了肠道微生物群的组成,增加了短链脂肪酸 (SCFA) 的产生,并增强了SCFA受体的表达.
- 素降低了促炎性细胞因子水平,并重新平衡了CD4+T细胞免疫力.
结论:
- 素显示出对过敏性腹和相关的肠道损伤的治疗潜力.
- 芝麻素的益处与其调节肠道微生物群并增强SCFA生产的能力有关.
- 需要对素作为与食物过敏有关的胃肠道疾病的治疗方法进行进一步的研究.
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