多发性骨髓瘤的新治疗方案
Andrew J Portuguese1,2, Rahul Banerjee1,2, GuiZhen Chen2
1Fred Hutchinson Cancer Center, Seattle, WA.
JCO oncology practice
|January 8, 2025
概括
最近的进展正在改变多发性骨髓瘤 (MM) 治疗,引入新型免疫疗法和向疗法. 个性化方法对于有效管理这种无法治愈的癌症至关重要.
科学领域:
- 血液瘤学 血液瘤学
- 免疫治疗是一种免疫疗法.
- 精准医学是一门精准的医学.
背景情况:
- 多发性骨髓瘤 (MM) 是一种普遍存在的血液性恶性瘤,其特征是治疗耐药性和复发.
- 尽管它是无法治愈的,但最近的突破正在彻底改变MM护理范式.
研究的目的:
- 审查从诊断到复发/耐药性疾病的多发性骨髓瘤 (MM) 的不断变化的治疗策略.
- 突出新型免疫疗法,向疗法和未来的研究药物的影响.
主要方法:
- 关于多发性髓瘤近期治疗进展的文献综述.
- 分析前线和复发/耐药环境中治疗模式的转变.
- 探索精准医学方法和新兴疗法.
主要成果:
- 前线MM治疗现在考虑了超出移植资格的四重组治疗的适用性.
- 新型免疫疗法,如CAR-T细胞和双特异性抗体,为复发性/耐药性MM提供了新的希望.
- 使用venetoclax的向治疗在t(11;14) 转位子组中显示出有效性.
结论:
- 新兴疗法,如研究中的CAR-T,cereblon E3结合酶调节剂,以及抗体-药物结合剂,有望改善反应.
- 挑战包括管理毒性,确保获取和优化治疗顺序以提供个性化护理.
- 随着治疗领域的扩大,平衡治疗效率和生活质量至关重要.
更多相关视频
07:24Repression of Multiple Myeloma Cell Growth In Vivo by Single-wall Carbon Nanotube SWCNT-delivered MALAT1 Antisense Oligos
Published on: December 13, 2018
6.4K
10:04Establishment of a Human Multiple Myeloma Xenograft Model in the Chicken to Study Tumor Growth, Invasion and Angiogenesis
Published on: May 1, 2015
13.0K
相关概念视频
Targeted Cancer Therapies
7.4K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.4K
Tumor Immunotherapy
472
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
472
Combination Therapies and Personalized Medicine
4.8K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
4.8K
Cancer Therapies
7.5K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
7.5K
Bone Marrow Sampling and Transplants
279
Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
279
Cancer Vaccines
337
Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
337
