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Updated: Jun 3, 2025

Combining 3D Magnetic Force Actuator and Multi-Functional Fluorescence Imaging to Study Nucleus Mechanobiology
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通过机械生物学调节细胞-纳米粒子相互作用

Marco Cassani1,2, Francesco Niro1,3,4, Soraia Fernandes1,2

  • 1International Clinical Research Center, St. Anne's University Hospital, 65691 Brno, Czech Republic.

Nano letters
|January 8, 2025
PubMed
概括

调节细胞机械感知通路,特别是河马通路.

关键词:
生物-纳米相互作用机械生物学 机械生物学机械传导 机械传导纳米颗粒是一种纳米粒子.

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Proteins perform many mechanical functions in a cell. These proteins can be classified into two general categories- proteins that generate mechanical forces and proteins that are subjected to mechanical forces. Proteins providing mechanical support to the structure of the cell, such as keratin, are subjected to mechanical force, whereas proteins involved in cell movement and transport of molecules across cell membranes, such as an ion pump, are examples of generating mechanical force. 
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The adherens junctions that anchor cells together are multi-protein complexes that dynamically adapt to mechanical stimuli such as tensile forces and shear stress. Mechanosensory proteins in these junctions can sense such mechanical stimuli and undergo a shift in their conformation, resulting in an altered function — a process called mechanotransduction.
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