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Updated: Jun 3, 2025

Methods for the Discovery of Novel Compounds Modulating a Gamma-Aminobutyric Acid Receptor Type A Neurotransmission
07:16

Methods for the Discovery of Novel Compounds Modulating a Gamma-Aminobutyric Acid Receptor Type A Neurotransmission

Published on: August 16, 2018

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基于自适应抽样的结构预测揭示了GABAA受体通过αβ接口的开放

Nandan Haloi1, Samuel Eriksson Lidbrink2, Rebecca J Howard1,2

  • 1SciLifeLab, Department of Applied Physics, KTH Royal Institute of Technology, Tomtebodävagen 23, Solna, 17165 Stockholm, Sweden.

Science advances
|January 8, 2025
PubMed
概括

研究人员模拟了玛-氨基黄油酸A型 (GABAA) 受体的开放状态,揭示了关键的结构变化和离子通道功能. 这种计算模型为药物标和复杂的膜蛋白提供了洞察力.

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Inhibitory Synapse Formation in a Co-culture Model Incorporating GABAergic Medium Spiny Neurons and HEK293 Cells Stably Expressing GABAA Receptors07:51

Inhibitory Synapse Formation in a Co-culture Model Incorporating GABAergic Medium Spiny Neurons and HEK293 Cells Stably Expressing GABAA Receptors

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