通过拉曼光谱和机械表征来评估下肢截肢者的皮肤适应性
Jack Hayes1, Jennifer Andrews2, Omar Abdelwahab3
1Department of Mechanical Engineering, Imperial College London, London, UK.
Journal of the Royal Society, Interface
|January 8, 2025
概括
下肢截肢者的皮肤无法适应使用假肢的负载. 相反,反复的摩擦会损害皮肤屏障功能,增加炎症,减少硬,需要新的治疗方法.
科学领域:
- 生物医学工程 生物医学工程
- 皮肤病学 皮肤病学
- 生物力学 生物力学
背景情况:
- 下肢截肢者的残余肢体皮肤是不承重的腿部皮肤.
- 假肢插座需要这种皮肤承受相当大的负载.
- 现有的假设表明,截肢者皮肤在使用假肢时会发生适应性变化.
研究的目的:
- 为了研究下肢截肢者的皮肤在机械负荷下的适应能力.
- 为了确定是否重复的摩擦创伤导致有益的承载适应.
- 评估皮肤屏障功能的变化,炎症,摩擦和硬.
主要方法:
- 混焦拉曼光谱法 混焦拉曼光谱法
- 机械表征 机械表征
- 细胞因子分析
主要成果:
- 截肢者的皮肤适应导致障碍功能受损.
- 观察到基线炎症增加,摩擦系数提高,度降低.
- 重复的摩擦创伤并没有赋予有益的承载适应.
结论:
- 非脚部皮肤与脚部皮肤不同,可能缺乏积极适应重复机械创伤的生物能力.
- 目前专注于机械调节或产品解决方案的治疗方法不足以提高承载能力.
- 皮肤三角学的多尺度分析对于开发有效的干预措施对于下肢截肢者至关重要.
更多相关视频
09:32Resolving Water, Proteins, and Lipids from In Vivo Confocal Raman Spectra of Stratum Corneum through a Chemometric Approach
Published on: September 26, 2019
7.1K
08:08Oscillation and Reaction Board Techniques for Estimating Inertial Properties of a Below-knee Prosthesis
Published on: May 8, 2014
16.7K
相关概念视频
Raman Spectroscopy Instrumentation: Overview
295
A conventional Raman spectrophotometer includes a laser source, a sample holding system, a wavelength selector, and a detector.
The monochromatic laser source, typically using visible or near-infrared radiation, generates a highly focused beam of light. This light interacts with the molecules of the sample, scattering some of the light. Liquid and gaseous samples are usually tested in ordinary glass capillaries, while solids can be analyzed as powders packed in capillaries or as potassium...
The monochromatic laser source, typically using visible or near-infrared radiation, generates a highly focused beam of light. This light interacts with the molecules of the sample, scattering some of the light. Liquid and gaseous samples are usually tested in ordinary glass capillaries, while solids can be analyzed as powders packed in capillaries or as potassium...
295
Raman Spectroscopy: Overview
305
The underlying principle of Raman spectroscopy is based on the interaction between light and matter, specifically molecules' inelastic scattering of photons. When a monochromatic beam of light, typically from a laser source, interacts with a sample, most scattered light has the same frequency as the incident light. This is known as Rayleigh scattering.
However, a small fraction of the scattered light exhibits a frequency shift due to the exchange of energy between the incident photons and...
However, a small fraction of the scattered light exhibits a frequency shift due to the exchange of energy between the incident photons and...
305
