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构成和表面活性剂模板对半孔生物活性玻璃的影响结构演变,生物活性和药物递送性质
Dana Almasri1, Yaser Dahman1,2
1Biomedical Engineering Graduate Program, Toronto Metropolitan University, Toronto, ON, Canada.
Journal of biomaterials applications
|January 8, 2025
概括
半孔生物活性玻璃 (MBGs) 提供先进的药物输送. 定制MBG成分和使用特定的表面活性剂,如Pluronic P123,可以增强药物负载,并使治疗应用的持续零顺序释放成为可能.
科学领域:
- 生物材料科学 生物材料科学
- 材料化学 材料化学
- 纳米技术纳米技术
背景情况:
- 半孔生物活性玻璃 (MBGs) 由于可调节的多孔性和生物仿真性质,对药物输送有希望.
- 了解MBG组成,合成和药物输送性能之间的相互作用对于优化治疗平台至关重要.
研究的目的:
- 系统地研究MBG成分和表面活性剂模板如何影响结构演变,生物活性,药物加载和释放动力学.
- 为开发基于MBG的先进药物输送系统建立结构-属性-功能关系.
主要方法:
- 通过不同的SiO2 / CaO含量和使用阴离子/非离子表面活性剂 (CTAB,F127,P123) 合成了12个sol-gel衍生的MBG样本.
- 使用电子显微镜和溶解,描述了MBG结构.
- 通过FTIR和SEM评估体外生物活性.
- 确定药物加载效率和释放动力学,将数据与数学模型相匹配.
主要成果:
- 实现了60-695m2/g的表面积的MBG,证实了有序的多孔结构.
- 对于70%-80%的SiO2配方,无论表面活性剂如何,都证明了加速酸的形成.
- 与其他表面活性剂相比,在与Pluronic P123合成的MBG中观察到更高的药物负载.
- 发现大多数MBG组合物表现出零顺序的药物释放动力学,表明持续的化.
结论:
- MBG的组成和表面活性剂模板显著影响结构性质,生物活性和药物载荷能力.
- 作为模板剂的Pluronic P123提高了MBG中的药物加载效率.
- 量身定制的层次架构和MBG的离子释放率使其能够实现先进的,持续的治疗交付功能.
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