跨脊柱刺激降低了健康人群在行走期间的屈曲反射通路的调节
Maria Knikou1,2,3, Abdullah M Sayed Ahmad1,2
1Klab4Recovery SCI Research Program, The City University of New York, Staten Island, New York, United States.
Journal of neurophysiology
|January 8, 2025
概括
走路时的脊梁间刺激会抑制健康个体前 (TA) 屈曲反射. 脊髓网络的这种神经调节可能有助于在脊髓损伤后恢复行走功能.
科学领域:
- 神经科学是一个神经科学.
- 发动机控制器的控制器
- 康复科学 康复科学 康复科学
背景情况:
- 前 (TA) 屈曲反射对于运动至关重要.
- 了解脊柱刺激如何影响反射是神经康复的关键.
- 跨脊柱刺激 (TSS) 是调节脊柱电路的潜在工具.
研究的目的:
- 为了研究在跑步机上行走时TA flexion反射的相位依赖调制.
- 为了确定跨脊柱刺激 (TSS) 在不同频率和强度对这一反射的影响.
- 探索TSS对调节涉及行走的脊髓神经网络的潜力.
主要方法:
- 参与者接受了15,30和50Hz的跨脊柱刺激 (TSS),在麻醉的上方和下方.
- 在跑步机上行走时,前部 (TA) 屈曲反射是由中枢足刺激引起的.
- 在整个步骤周期中测量了反射活动,并将其正常化到最大的TA活动.
主要成果:
- 无条件曲反射显示在走路时的相位依赖调制.
- 在所有测试的频率和强度上,TSS始终产生了TA flexion反射的明显抑制.
- 这种抑郁发生在不改变反射活动和背景EMG之间的关系的情况下,这表明特定的途径调节.
结论:
- 跨脊柱刺激 (TSS) 在健康人群中有效地降低了前 (TA) 曲反射在行走过程中.
- 研究结果表明,TSS主要影响曲反射通路,而不是延伸通路 (如单身H反射).
- 这种脊髓网络的神经调节为通过抑制夸张的反射来改善脊髓损伤后的行走提供了潜在的治疗益处.
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