主观认知衰退预测了脑健康登记处在无监督的在线环境中纵向神经心理测试的表现
Jae Myeong Kang1,2,3, Manchumad Manjavong1,2,4, Chengshi Jin5
1Department of Psychiatry and Behavioral Sciences, University of California San Francisco, San Francisco, CA, USA.
Alzheimer's research & therapy
|January 8, 2025
概括
用日常认知量表 (ECog) 测量的主观认知下降,有效预测在线评估中的客观认知下降. 这一发现支持使用自我管理的工具来早期检测认知障碍.
科学领域:
- 神经科学是一个神经科学.
- 老年学是指老年学的学科.
- 心理学 心理学 心理学
背景情况:
- 数字评估提供了有效的认知衰退早期检测.
- 很少有研究探讨了远程收集的主观认知变化和客观衰退之间的联系.
- 日常认知量表 (ECog) 衡量主观认知变化.
研究的目的:
- 调查日常认知量表 (ECog) 是否预测大脑健康注册表 (BHR) 中的纵向认知变化.
- 评估在线,自我管理的主观认知措施在识别认知衰退方面的实用性.
主要方法:
- 来自BHR的16,683名55岁以上的参与者完成了基线ECog和重复的CANTAB®配对协同学习 (PAL) 测试.
- 分析了自我报告 (Self-ECog) 和研究合作伙伴报告 (SP-ECog) 的ECog分数.
- 估计了ECog分数和PAL (FAMS,TEA) 的纵向变化之间的关联,根据PAL最差的进展斜率确定了"下降点".
主要成果:
- 自声回应阳性和自声回应一致的得分都在PAL FAMS中显著预测了纵向变化 (p < 0.001).
- 较高的自我ECog总分 (OR=1.390) 和SP-ECog一致报告 (OR=2.417) 增加了根据PAL FAMS被确定为认知衰退的可能性.
结论:
- 在线环境中通过ECog评估的基线主观认知变化可以预测神经心理测试的纵向下降.
- 在线,自我管理的主观认知变化措施显示出预测客观变化和识别认知障碍的个体的潜力.
相关概念视频
01:30Cognitive Development During Adulthood
50
Cognitive development continues throughout adulthood, undergoing significant shifts across early, middle, and late stages. Individual transition occurs from adolescent idealism to pragmatic and adaptable thinking in early adulthood. During this period, individuals learn to integrate personal beliefs with the recognition that other perspectives are equally valid. Exposure to the complexities of modern society, diverse experiences, and higher education contribute to this adaptive thought process,...
50
02:20Longitudinal Research
11.8K
Sometimes we want to see how people change over time, as in studies of human development and lifespan. When we test the same group of individuals repeatedly over an extended period of time, we are conducting longitudinal research. Longitudinal research is a research design in which data-gathering is administered repeatedly over an extended period of time. For example, we may survey a group of individuals about their dietary habits at age 20, retest them a decade later at age 30, and then again...
11.8K
01:26Alzheimer's Disease: Overview
444
Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
444
01:26Longitudinal Studies
128
Longitudinal studies are also widely used in other medical and social science fields. For instance, in cardiovascular research, they can monitor patients' health over decades to identify risk factors for heart disease, such as high cholesterol or smoking, and evaluate the long-term effectiveness of preventive measures. Similarly, in mental health studies, researchers might follow individuals from adolescence into adulthood to understand the development and progression of conditions like...
128