相关实验视频

Updated: Jun 3, 2025

Establishment and Characterization of UTI and CAUTI in a Mouse Model

Establishment and Characterization of UTI and CAUTI in a Mouse Model

Published on: June 23, 2015

复杂的尿路感染:关于新兴和正在开发的抗生素的最新情况

Silvia Guerriero¹, Elena Matteini¹, Maya M Gross¹

¹Dipartimento di Sicurezza e Bioetica, Sezione di Malattie Infettive, Università Cattolica del Sacro Cuore, Rome, Italy.

Expert opinion on pharmacotherapy

|January 8, 2025

概括

管理复杂的尿路感染 (CUTIs) 需要及时,有针对性的抗生素治疗. 以患者为中心的方法和更新的定义可以改善结果并减少抗菌素耐药性.

科学领域:

传染性疾病传染性疾病
药理学药理学是指药理学的学科.
抗微生物耐药性抗微生物耐药性

背景情况:

复杂的尿路感染 (CUTIs) 对健康构成重大风险,包括败血症,高发病率和死亡率.
有效管理CUTIs需要及时和精确的干预措施,以防止严重的并发症和复发.

研究的目的:

审查当前和新兴的抗生素策略来治疗切口感染.
强调抗微生物药物管理和精确诊断在治理CUTIs方面的重要性.
建议修订cUTI的定义,以优化治疗和减少不必要的抗生素暴露.

主要方法:

对现有和新兴抗生素用于治疗CUTI的文献综述.
对药理动力学/药理动力学因素和局部耐药性模式的分析.
评估影响治疗选择的患者特定因素.

主要成果:

几种抗生素类别,包括β-乳糖胺,诺基诺,氨基糖化物和β-乳糖酶抑制剂组合,在cUTI中显示出对多药耐药生物体 (MDROs) 的承诺.
以耐药性概况和患者因素为指导的早期,有针对性的抗生素治疗至关重要.
更广泛的CUTI定义可能会导致过度使用抗生素和住院治疗.

结论:

抗微生物药物管理,精确的诊断和创新疗法对于打击cUTIs和抗微生物药物耐药性至关重要.
针对性,以患者为中心的方法优化了结果,并减少了耐药感染的影响.
重新审视cUTI的定义可以促进务实的管理,并尽量减少不必要的抗生素使用.

关键词:

复杂的尿路感染.抗微生物疗法是一种抗微生物疗法.细菌的耐药性细菌的耐药性临床结果的临床结果.炎症标志物的炎症标志物治疗时间治疗时间

更多相关视频

Isolation of Single Intracellular Bacterial Communities Generated from a Murine Model of Urinary Tract Infection for Downstream Single-cell Analysis

Isolation of Single Intracellular Bacterial Communities Generated from a Murine Model of Urinary Tract Infection for Downstream Single-cell Analysis

Published on: April 16, 2019

Urinary Tract Infection in a Small Animal Model: Transurethral Catheterization of Male and Female Mice

Urinary Tract Infection in a Small Animal Model: Transurethral Catheterization of Male and Female Mice

Published on: December 1, 2017

相关概念视频

Combined Effects of Drugs: Synergism

Combined Effects of Drugs: Synergism

Synergism is a useful mechanism where combining two or more drugs is more effective than each constituent used alone. Such combinations are also called supra-additive interactions. The drugs collectively enhance the final therapeutic effect by acting on different targets. Another advantage is that the low dose of each constituent drug is sufficient to achieve the desired effect. This helps reduce the duration of therapy and lower the adverse effects of these drugs.
Such synergistic combinations...

Antibiotic Selection

Antibiotic Selection

Disorders of the Urinary System

Disorders of the Urinary System

The urinary system is responsible for eliminating waste and excess fluids from the body. However, disorders of the urinary system can arise due to various reasons like infections, stress, age, congenital abnormalities, and lifestyle.
Urinary tract infections (UTIs) are one of the most common urinary system disorders. They are caused by bacteria that enter the urethra and can spread to the bladder resulting in cystitis. Pyelonephritis is the result of a UTI that has ascended to the level of the...

Sexually Transmitted Infections

Sexually Transmitted Infections

Sexually transmitted infections (STIs) are diseases transmitted primarily through unsafe sexual interactions. Bacteria, viruses, or parasites cause them and can result in severe health complications if untreated.ChlamydiaThe bacterium Chlamydia trachomatis is responsible for the disease Chlamydia, the most common STI in the United States. This peculiar pathogen requires human cells to reproduce, residing intracellularly. The initial infection often goes unnoticed because it typically does not...

Microorganisms in Medicine and Therapeutics

Microorganisms in Medicine and Therapeutics

Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.

Drug Elimination by Renal Route: Tubular Secretion

Drug Elimination by Renal Route: Tubular Secretion

Once the process of glomerular filtration is completed, blood carrying unfiltered drug molecules traverses through efferent arterioles and makes its way into the peritubular capillaries in the proximal tubule. A variety of carriers play a pivotal role in actively secreting drugs from these peritubular capillaries into the tubular fluid. The organic anion transporter transfers acidic drugs, against an electrochemical gradient, from the peritubular capillaries into the renal tubule cells and...