双边视网母细胞瘤患者的大脑MRI查
Ronald Hershcovici1, Shahar Frenkel1,2, Gal Goldstein3
1Faculty of Medicine, The Hebrew University, Jerusalem, Israel.
Seminars in ophthalmology
|January 8, 2025
概括
在双边视网膜母细胞瘤患者中,针对三边视网膜母细胞瘤 (TRB) 的常规脑部MRI查可能足够. 这种方法可以避免麻醉和不必要的干预,而不会显著影响生存率.
科学领域:
- 眼科医生 眼科 眼科
- 儿科瘤学 儿科瘤学
- 神经瘤学神经瘤学
背景情况:
- 三边视网膜母细胞瘤 (TRB) 是一种罕见的,致命的内瘤,与遗传性视网膜母细胞瘤相关.
- 对于TRB的常规脑成像查,关于其对生存和治疗所需人数的影响仍在争论中.
- 眼科瘤中心通常通过脑成像对视网膜母细胞瘤患者进行查.
研究的目的:
- 评估推的查计划 (基线脑成像,其次是基于临床需要的成像) 对双边视网膜母细胞瘤患者的生存的影响.
- 为了确定常规查脑成像是否会延长TRB患者的存活时间.
主要方法:
- 在1986年至2020年期间诊断的109名双边视网膜母细胞瘤患者的回顾性观察研究.
- 收集的数据包括人口统计,临床特征,系统评估,治疗,随访和结果.
- 基线和随访脑成像 (MRI/CT) 和生存数据的分析.
主要成果:
- 在109名患者中,53%的患者有基线脑成像,所有这些都在正常范围内.
- 在平均138个月的随访期间,一名患者 (0.9%) 出现了症状TRB,并且没有疾病.
- 八名患者 (7.3%) 因与视网膜母细胞瘤相关的原因而死亡;六人患有转移性疾病.
结论:
- 针对TRB的常规基线脑MRI查可能是充足的,可能避免麻醉,成本和痛苦而不会危及生存.
- 由于TRB的致死率和治疗致病率,定期的大脑MRI直到3岁仍然是一个可行的选择.
相关概念视频
01:20The Retinoblastoma Gene
4.0K
Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
4.0K
01:24Magnetic Resonance Imaging
4.9K
Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...
4.9K