与免疫相关的不良事件与晚期或转移性胃食道癌的生存无关
Omar Elghawy1, Reema Patel2, Abhishek Mullapudi2
1Department of Internal Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA, USA.
Journal of chemotherapy (Florence, Italy)
|January 8, 2025
概括
免疫检查点抑制剂 (ICI) 在胃癌和食道癌 (GEC) 方面表现有前途. 然而,在这项研究中,GEC患者的免疫相关不良事件 (IRAE) 与改善的生存结果没有相关性.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
背景情况:
- 免疫检查点抑制剂 (ICI) 是胃癌和食道癌 (GEC) 的有希望的治疗方法.
- 免疫相关不良事件 (IRAE) 是已知的ICI的副作用.
- 其他癌症的先前研究表明,IRAE可能与改善的治疗反应相关.
研究的目的:
- 调查ICI治疗的高级GEC患者中IRAE的发生率.
- 为了确定IRAE是否与GEC的治疗反应 (无进展生存率和总生存率) 有关.
主要方法:
- 一个机构的回顾性研究.
- 对70名接受ICI治疗的晚期GEC患者的分析.
- 具有和没有IRAE的患者之间的无进展生存 (PFS) 和整体生存 (OS) 的比较.
主要成果:
- 29%的GEC患者发生了IRAE.
- 最常见的IRAE包括大肠炎,甲状腺功能低下和肺炎.
- 在具有和没有IRAE的患者之间没有观察到PFS或OS中位数的统计学上显著差异.
结论:
- 在先进的GEC中,IRAE的发生率很大.
- 与其他癌症类型的发现不同,GEC患者的IRAE与改善PFS或OS无关.
- 需要进一步的研究来了解IRAE在GEC治疗结果中的作用.
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