在年轻人群中增加了MASH相关的肝癌
Pojsakorn Danpanichkul1, Yanfang Pang2,3,4,5, Kanokphong Suparan6
1Department of Internal Medicine, Texas Tech University Health Sciences Center, Lubbock, Texas, USA.
Hepatology communications
|January 8, 2025
概括
与代谢功能障碍相关的脂肪肝炎 (MASH) 相关的原发性肝癌 (PLC) 的发生率在全球年轻人中正在上升. 迫切需要全球战略来解决这个日益严重的公共卫生问题.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 在瘤学瘤学.
- 代谢疾病 代谢疾病
背景情况:
- 在年轻人中癌症和代谢疾病的发病率增加.
- 在这个人口群体中,关于代谢功能障碍相关的脂肪肝炎 (MASH) 和相关的原发性肝癌 (PLC) 的全球数据有限.
- 与代谢功能障碍相关的脂肪性肝病的患病率上升.
研究的目的:
- 分析MASH相关的PLC发病率和年轻成年人死亡率的全球趋势.
- 为了评估MASH相关的PLC负担,使用残疾调整寿命年 (DALYs).
- 在年轻成年人中识别MASH相关的PLC率的区域差异.
主要方法:
- 利用了2000年至2021年的全球疾病负担研究数据.
- 评估了15-49岁个人中MASH相关PLC的年龄标准化发病率,死亡率和DALY率.
- 分析了年度百分比变化和区域差异.
主要成果:
- 在2021年,MASH相关的PLC在年轻人中占了4300例,3550例死亡和179,340例DALY.
- 与MASH相关的PLC显示发病率上升 (APC: +0.26%),其中东地中海地区的增幅最高 (APC: +1.46%).
- 超过一半的国家在2000-2021年间,在年轻成年人中,MASH相关的PLC的年龄标准化发病率增加.
结论:
- 年轻成年人中MASH相关PLC的发病率正在显著增加.
- 这一趋势预测,随着队列年龄的增长,老年人群中的PLC发病率将在未来上升.
- 迫切需要全球战略来打击MASH相关的PLC流行病在年轻人中.
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